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CD28 — TNF

Text-mined interactions from Literome

Lin et al., Immunity 1999 : Conversely, expression of kinase-deficient Cot inhibits CD3/CD28 but not TNF alpha induction of NF-kappaB
Sakuma et al., Br J Pharmacol 2000 : FK506 inhibited anti-CD3/CD28 induced TNF-alpha and IL-1beta production at concentrations less than 1 ng ml(-1)
Gonzalo et al., J Immunol 2001 : Our data suggest that ICOS and CD28 regulate T cell expansion and that ligation of either CD28 or ICOS can either uniquely regulate cytokine production ( IL-2/TNF-alpha ) or synergize for optimal cytokine production ( IL-4 ) after SAg administration
Bryl et al., J Immunol 2001 (Arthritis, Rheumatoid) : In reporter gene bioassays, TNF-alpha was found to inhibit the activity of the CD28 minimal promoter
von Fliedner et al., Cell Immunol 1992 : These results thus document that T cell activation via CD28 results in a marked increase in TNF-alpha production without affecting the functional disparity that exists between naive and memory T cells
Lewis et al., J Biol Chem 2004 : Tumor necrosis factor-alpha reduced CD28 expression because of the inhibition of INR-driven transcription
Magari et al., Inflamm Res 2004 (Arthritis...) : LEF inhibited anti-CD3/CD28 induced production of TNF-alpha , IL-1beta and IL-6, with IC50 values of 27, 21 and 21 microg/ml, respectively
Kohm et al., Cell Immunol 2005 : CD28 regulates glucocorticoid induced TNF receptor family related gene expression on CD4+ T cells via IL-2 dependent mechanisms
Tamma et al., J Leukoc Biol 2006 : However, compared with stimulation with phorbol 12-myristate 13-acetate plus ionomycin, jacalin plus CD28XL resulted in decreased levels of tumor necrosis factor alpha secretion
Honstettre et al., Infect Immun 2006 : The CD28 deficiency had no effect on either granuloma formation, which reflects cell mediated immunity against C. burnetii, or the production of gamma interferon and tumor necrosis factor , two cytokines known to be involved in granuloma formation
Sánchez-Valdepeñas et al., J Immunol 2006 : Splenic T cells from aly/aly mice ( that have a defective NIK protein ) have a severe impairment in IL-2 and GM-CSF but not TNF secretion in response to CD3/CD28
Assi et al., Immunology 2006 (Colitis, Ulcerative...) : Both total colonic and mesenteric lymphocyte CD3/CD28 stimulated TNF-alpha levels were dramatically reduced under the same circumstances
Marin et al., Exp Hematol 2007 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : Moreover, the presence of 4-1BB or CD28 in the receptor increased the production of interleukin (IL)-2, tumor necrosis factor (TNF)-alpha , TNF-beta, IL-5, IL-6, and IL-8 elicited by coculture with ALL cells
Tyagi et al., Osteoporos Int 2012 (Disease Models, Animal...) : Further, Med abrogated TNF-a induced loss of CD28 expression in the BM T cells
Römer et al., Blood 2011 : Preclinical tests using human PBMCs had failed to announce the rapid release of TNF , IFN-?, and other toxic cytokines in response to this CD28 "superagonist" (CD28SA)
Telang et al., Journal of translational medicine 2012 (Hypersensitivity, Delayed) : We then determined the effect of 3PO on anti-CD3/anti-CD28 induced T cell activation, F2,6BP synthesis, 2- [ 1-14C ] -deoxy-d-glucose uptake, lactate secretion, TNF-a secretion and proliferation
Nandi et al., J Immunol 1994 : IL-2 activated NK cells produced enhanced levels of IFN-gamma and TNF in response to stimulation with anti-CD28 and PMA
Verwilghen et al., J Immunol 1993 : CD5/CD28 ligation induced production of TNF-alpha , but not of IL-4, and did not induce modulation of the TCR/CD3 complex
Costello et al., Eur J Immunol 1993 : CD28 associated to CD3 or CD2 induced high levels of IL-2, tumor necrosis factor (TNF) and IL-4 secretion for 10 days, in contrast to CD3 alone which induced only TNF secretion
Chen et al., J Biol Chem 1996 : The c-Jun N-terminal kinases (JNK) are activated by various stimuli, including UV light, interleukin-1, tumor necrosis factor-alpha (TNF-alpha), and CD28 costimulation
Lin et al., J Immunol 1997 : TNF receptor-2 triggered apoptosis is associated with the down-regulation of Bcl-xL on activated T cells and can be prevented by CD28 costimulation
Dumont et al., J Immunol 1998 : FK506 also reduced CD3/CD28 induced production of IL-3, IL-4, IL-10, TNF-alpha , and IL-6 but augmented that of GM-CSF, IL-5, IFN-gamma, and IL-13
Ballester et al., J Biol Chem 1998 : Expression of a dominant negative form of Cot kinase inhibits TNF-alpha promoter activation induced by stimulation with either calcium ionophore and PDBu, soluble anti-CD28 and PDBu, or soluble anti-CD3 and PDBu