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SYK — ZAP70

Pathways - manually collected, often from reviews:

• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
  Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
  Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
  Evidence: mutant phenotype, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• Gene Ontology Complexes T cell receptor complex: T cell receptor complex complex (CD247-SYK-CD8B-CD3D-ZAP70) Allam et al., Immunobiology 2000*, Weissman et al., Nature 1986*, Chan et al., J Immunol 1994, San José et al., Eur J Immunol 1998

Text-mined interactions from Literome

Steinberg et al., Blood 2004 (Leukemia, Lymphocytic, Chronic, B-Cell) : Importantly, the presence of ZAP-70 positively regulates the TCR induced tyrosine phosphorylation of Syk
Zou et al., J Cell Biochem 2013 : In keeping with arrested cytoskeletal organization, Zap70 blocks integrin activated endogenous Syk and Vav3, SLP76 phosphorylation
Taylor et al., Blood 1997 (Second Messenger Systems) : Neither Syk nor MAP kinase activation was affected by the presence of ZAP-70