Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
MEF2D
→
PPARGC1A
(increases, PPARGC1A Activity, MEF2D Activity)
Handschin et al., Proc Natl Acad Sci U S A 2003* Evidence: The PGC-1-alpha -expressing mice showed increased expression of myofibrillar proteins characteristic of type I fibers, a higher expression of components of the mitochondrial electron transport system, and greater resistance to fatigue than wild-type mice. MEF2 proteins, especially MEF2C and MEF2D, seem to be important targets of PGC-1-alpha in the coactivation of several type I-selective promoters.
OpenBEL Selventa BEL large corpus:
MEF2D
→
PPARGC1A
(increases, PPARGC1A Activity, MEF2D Activity)
Handschin et al., Proc Natl Acad Sci U S A 2003* Evidence: Although CREB thus seems to be an important factor in the induction of PGC-1-alpha , the increased effect of CaMKIV in combination with CnA suggests that factors in addition to CREB are likely to be involved in the transcription of the PGC-1-alpha gene in muscle. Because MEF2 and NFAT transcription factors are known targets of CaMKIV and CnA in muscle fiber-type determination, we tested the role of these factors in the control of the PGC-1-alpha promoter. MEF2C, MEF2D, or NFATc3 alone did not h...