Qiao et al., J Biol Chem 2004
:
However, an inhibitor of the p21 activated protein kinase-1, glutathione S-transferase-Pak1- ( 83-149 ), inhibited both basal and IGF-1 stimulated RUNX2 DNA binding, suggesting that Pak1 mediates IGF-1 signaling to increase RUNX2 activity
Lessmann et al., Exp Hematol 2006
:
Ins/IGF-1 , like antigen ( Ag ), also stimulates the Rac dependent activation of PAK as well as the production of hydrogen peroxide ( H2O2 )