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KRT8 — MAPK8

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: KRT8 → MAPK8 (directlyIncreases, KRT8 Activity) He et al., J Biol Chem 2002*
  Evidence: One example is K8 Ser-73, which has been implicated as an important phosphorylation site during mitosis, cell stress, and apoptosis. We show that K8 is strongly phosphorylated on Ser-73 upon stimulation of the pro-apoptotic cytokine receptor Fas/CD95/Apo-1 in HT-29 cells. Kinase assays showed that c-Jun N-terminal kinase (JNK) was also activated with activation kinetics corresponding to that of K8 phosphorylation. Furthermore, K8 was also phosphorylated on Ser-73 by JNK in vitro, yielding simila...

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAPK8 — KRT8 (physical association, affinity chromatography technology) He et al., J Biol Chem 2002*
• IRef Hprd Interaction: MAPK8 — KRT8 (in vitro) He et al., J Biol Chem 2002*, Ku et al., J Biol Chem 2002*, Liao et al., J Biol Chem 1997*
• IRef Hprd Interaction: MAPK8 — KRT8 (in vivo) He et al., J Biol Chem 2002*, Ku et al., J Biol Chem 2002*, Liao et al., J Biol Chem 1997*