Lin et al., Oncogene 2001
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vIRF-1 has been shown to downregulate the interferon- and IRF mediated transcriptional activation of ISG and murine IFNA4 gene promoters
Chiang et al., J Immunol 2006
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In this study we show that IRF3 mediated ISG induction by LPS requires the production of reactive oxygen species ( ROS ) by the NADPH dependent oxidase NOX4 ... ASK1 kinase activity proved essential for IRF3 mediated ISG induction by LPS Seppola et al., Dev Comp Immunol 2007
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The expression of ISG15 in head kidney cells was also induced in vitro by treatment with poly I:C, but not significantly with LPS