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CYP2B6 — IRF6
Text-mined interactions from Literome
Li-Masters et al., Drug Metab Dispos 2001
:
The effects of LPS on expression of phenobarbital ( PB ) -induced CYP2B1/2 in rats have been well characterized, but less is known about the
effects of
LPS on PB-induced
CYP2B in mice ... Since genetically manipulated mice represent an attractive model to study the mechanisms involved in the down-regulation of CYP2B expression by LPS, we investigated the
effects of
LPS on PB-induced
CYP2B expression in mouse liver ...
LPS inhibited the mRNA expression of
CYP2B10 and CYP2B9 at 6 and 12 h of treatment, with the inhibitory effect more profound at 12 h. LPS also suppressed the CYP2B9 mRNA level at 24 h
Khatsenko et al., Toxicol Lett 1997
:
Here, we report that endogeneous nitric oxide also contributes to
LPS induced suppression of
CYP2B1/2 in vivo by down regulating the expression of CYP2B1/2 protein and mRNA
Mahéo et al., Hepatology 1998
:
Moreover, it is shown that oltipraz
induction of CYP1A2 and
CYP2B1/2 and its suppression by E. coli
LPS occurred at a transcriptional level