Gene interactions and pathways from curated databases and text-mining

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CORT — IRF6

Text-mined interactions from Literome

Mancuso et al., J Neuroimmunol 1999 : SnPP9 given i.p. failed to modify either basal or LPS stimulated levels of AVP and Cort
Johnson et al., J Neuroimmunol 2006 : Age and hormone effects on pituitary cytokines were also mirrored in plasma corticosterone (CORT) levels, such that estrogen treatment to senescent females attenuated LPS induced CORT
Munhoz et al., J Neurosci 2010 (Inflammation) : In the absence of LPS , elevated CORT levels increased basal activation of ERK1/2, p38, SAPK/JNK, and AKT in both regions
Cui et al., J Endocrinol 2011 : Plasma corticosterone (Cort) and ACTH responses to LPS were well maintained in pregnant rats at embryonic days 15/16 ( E15/16 ) and E18/19 compared to non-pregnant rats ... In non-pregnant animals, pretreatment with the GC synthesis inhibitor, metyrapone, inhibited the LPS induced increase in IL-6, and the IL-6 response was restored by Cort replacement, indicating that LPS induction of IL-6 is Cort dependent ... In E15 pregnant animals, metyrapone had no effect on LPS induced IL-6 levels, indicating that LPS-induction of IL-6 is not dependent on Cort
Mekaouche et al., Neuroimmunomodulation 1994 : In contrast, the ACTH and CORT post-LPS responses were normal in the OR group
Givalois et al., C R Seances Soc Biol Fil 1995 : When injected through an intra-arterial ( i. a. ) cannula, LPS induced a rapid ( 15-30 min ) and long lasting ( > 300 min ) increase in plasma ACTH and corticosterone (CORT) levels
Givalois et al., Neuroendocrinology 1996 : Blockade of histaminergic receptors by intra-arterial pretreatment with H1 or H2 antagonists ( mepyramine, 1 mg/rat, and cimetidine, 2 mg/rat ), administered separately, did not affect either ACTH or CORT responses to LPS
Nakamura et al., Poult Sci 1998 : This study suggests that E. coli LPS may elevate serum IL-6 and CORT, and that IL-6 and CORT may increase the alpha1-AG level in the chicks