Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
BLVRA
→
INSR
(directlyIncreases, BLVRA Activity)
Evidence: The ability of BVR to activate expression of these genes was established in 293A cells from human embryonic kidney transfected with an adenoviral construct containing BVR. BVR is a bzip-type transcription factor that binds in dimeric form to AP-1 sites. Activation of AP-1 is the key event in oxidative stress response of ho-1 and other stress proteins (54). BVR regulates cellular levels of biliverdin, a potent gene regulator as illustrated by its being the determinant factor for dorsal axis devel...