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IL6 — LPA

Text-mined interactions from Literome

Buechler et al., Biochim Biophys Acta 2003 (Coronary Artery Disease...) : Lipoprotein (a) downregulates lysosomal acid lipase and induces interleukin-6 in human blood monocytes ... Purified Lp(a) led to an increased secretion of IL-6 , but not TNF-alpha arguing against a general activation of these cells ... In addition, increased levels of IL-6 also predict future cardiovascular events and IL-6 secretion was also induced by purified Lp(a)
Fang et al., J Biol Chem 2004 (Ovarian Neoplasms) : In the current study, we demonstrated that LPA is a potent inducer of interleukin-6 (IL-6) and interleukin-8 (IL-8) production in ovarian cancer cells ... Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines ... These studies elucidate the transcriptional mechanism and the Edg LPA receptors involved in LPA induced IL-6 and IL-8 production and suggest potential strategies to restrain the expression of these cytokines in ovarian cancer
Sivashanmugam et al., J Biol Chem 2004 (Prostatic Neoplasms) : Our findings reveal that the LPA regulated secretion of IL-6 is an important messenger linking stromal and epithelial prostate cells, which may be exploited for the effective treatment of patients with advanced prostate cancer
Klemm et al., Proc Natl Acad Sci U S A 2007 : In a biological readout, we demonstrate that LPA induced IL-6 production is abolished in the absence of Bcl10
Said et al., Neoplasia (New York, N.Y.) 2007 (Neoplasm Invasiveness...) : Moreover, our results show that SPARC not only significantly inhibited both basal and LPA induced interleukin (IL) 6 production in both cell lines but also attenuated IL-6 induced mitogenic, chemotactic, and proinvasive effects, in part, through significant suppression of ERK1/2 and, to a lesser extent, of signal transducers and activators of transcription 3 signaling pathways ... Our results strongly suggest that SPARC exerts a dual inhibitory effect on LPA induced mesothelial-ovarian cancer cell crosstalk through the regulation of both LPA induced IL-6 production and function
Zhao et al., Mol Pharmacol 2008 (Arthritis, Rheumatoid) : Moreover, exogenously applied LPA induces FLS migration and secretion of IL-8/IL-6 , whereas the LPA ( 3 ) agonist l-sn-1-O-oleoyl-2-methyl-glyceryl-3-phosphothionate ( 2S-OMPT ) stimulates cytokine synthesis but not cell motility
Fan et al., Mol Med 2008 (Endotoxemia...) : LPA ( 1 and 10 microM ) significantly inhibited LPS induced TNFalpha production ( 61 +/- 9 % and 72 +/- 9 %, respectively, P < 0.05 ) but not IL-6
Chen et al., Endocrinology 2008 : The effects of LPA on the expression of vascular endothelial growth factor, IL-6 , and IL-8 were examined
Hao et al., Am J Physiol Heart Circ Physiol 2010 : LPA induces IL-6 secretion from aortic smooth muscle cells via an LPA1 regulated, PKC dependent, and p38alpha mediated pathway ... However, LPA induction of IL-6 secretion from vascular SMCs and its regulatory mechanism are unknown ... The present study reveals that LPA induces the expression of IL-6 mRNA and protein in HASMCs as well as the secretion of IL-6 protein in a time dependent manner ... Our results demonstrate that LPA-specific receptor 1 ( LPA ( 1 ) ) mediates LPA induced IL-6 secretion and that LPA induction of IL-6 is independent of the EGF receptor pathway ... Finally, small interfering RNA depletion experiments revealed that p38alpha is specifically responsible for the LPA induced IL-6 secretion ... The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA induced IL-6 production in HASMCs
Boucharaba et al., Oncol Res 2009 (Breast Neoplasms) : S1P, but not LPA, controlled the expression of VEGF-A by breast cancer cells, while LPA , but not S1P, controlled the expression of GM-CSF, Gro-alpha, MCP-1, and IL-6
Azuma et al., Biochem Biophys Res Commun 1996 (Hepatoblastoma...) : All-trans-retinoic acid ( ATRA ) and interleukin-6 increased the transcriptional activity of the apo(a) gene promoter 2.1- and 2.5-fold, respectively, whereas danazol reduced activity to 76 % of the control value
Wooten et al., J Immunol 1998 : Lipoprotein mediated induction of nuclear factor-kappaB nuclear translocation and production of IL-8 and IL-6 in HUVEC was enhanced in the presence of serum or soluble rCD14
Ramharack et al., Arterioscler Thromb Vasc Biol 1998 : Mixing experiments, in which hepatocytes were treated with 10 ng/mL of IL-6 and 0.3 to 10 ng/mL of TGF-beta1 or TNF-alpha, demonstrated that the IL-6 mediated induction of Lp(a) and apo(a) mRNA was ablated with very low levels of either inhibitory cytokine, suggesting a dominant negative effect of TGF-beta1 and TNF-alpha