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GAB2 — IL15

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: GAB2 → IL15 (increases)
  Evidence: We show that Gab2 was transiently phosphorylated by tyrosine in human mycosis fungoides (MF) tumor T cells upon IL-2 stimulation and that SHP2 as well as Stat5a associated inducibly with Gab2. IL-15, but not IL-4, also induced tyrosine phosphorylation of Gab2, suggesting that the IL-2 receptor beta-chain is important for IL-2-induced Gab2 phosphorylation.

Text-mined interactions from Literome

Gadina et al., J Biol Chem 2000 : We also demonstrate that only IL-2 and IL-15 , but not other gammac cytokines induce Gab2 phosphorylation ; the ability to phosphorylate Gab2 correlates with Shc phosphorylation and ERK1/ERK2 activation
Yamasaki et al., J Biol Chem 2001 : Overexpression of Gab2 in Jurkat cells or antigen-specific T cell hybridomas resulted in the inhibition of NF-AT activation, interleukin-2 production, and tyrosine phosphorylation