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IL13 — MUC5AC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MUC5AC → IL13 (increases) Deshmukh et al., Am J Respir Crit Care Med 2005*
  Evidence: Multiple agents, including cigarette smoke (15), activated eosinophils (16), interleukin-13 (17), neutrophil elastase (18), Pseudomonas aeruginosa (19), and phorbol 12-myristate 13- acetate (PMA) (20) increase MUC5AC in airway epithelial cells (NCI-H292)...

Text-mined interactions from Literome

Kibe et al., Am J Respir Crit Care Med 2003 (Eosinophilia...) : Treatment with dexamethasone inhibited eotaxin expression and completely abolished eosinophil accumulation, but it did not affect AHR, MUC5AC overexpression, or goblet cell hyperplasia induced by IL-13
Liu et al., Zhonghua Jie He He Hu Xi Za Zhi 2004 (Asthma...) : [ Effects of interleukin-13 on the gob-5 and MUC5AC expression in lungs of a murine asthmatic model ]
Liu et al., J Huazhong Univ Sci Technolog Med Sci 2004 : Effects of glucocorticoid on IL-13 induced Muc5ac expression in airways of mice ... To study the effects of glucocorticoid on the IL-13 induced Muc5ac expression in airways of mice, and investigate its role in mucus secretion of airways, 24 pathogen-free BALB/c mice were randomly divided into 3 groups
Yasuo et al., Respiration 2006 (Hyperplasia) : However, the relationship between human calcium activated chloride channel-1 ( hCLCA1 ) and MUC5AC induced by IL-13 in vitro has not been fully investigated ... IL-13 might induce the expression of MUC5AC and hCLCA1 gene and protein in well differentiated NHBE cells
Fujisawa et al., Respirology 2008 (Metaplasia) : Cycloheximide also diminished activation of p38 MAPK and induction of MUC5AC mRNA expression by IL-13 ... The p38 MAPK pathway is involved in IL-13 induced mucous cell metaplasia and MUC5AC mRNA regulation in mTEC
Malavia et al., Respir Res 2008 (Pulmonary Fibrosis) : IL-13 induced increasing levels of MUC5AC protein, and TGF-beta2, while decreasing beta-Tubulin IV at day 22 and 28 in the NHBE
Zhao et al., Am J Respir Crit Care Med 2009 (Asthma) : Interleukin-13 induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells ... Inhibition of 15LO1 suppressed 15-HETE-PE and decreased MUC5AC expression in the presence of IL-13 stimulation ... IL-13 induction of 15-HETE-PE enhances MUC5AC expression in human airway epithelial cells
Kono et al., Pulm Pharmacol Ther 2010 (Asthma) : These results suggest that SphK1 is involved in MUC5AC production induced by IL-13 upstream of ERK1/2 phosphorylation, and independent of STAT6 phosphorylation
Yadav et al., PloS one 2010 (Metaplasia) : Further, IL-13 significantly increased the expression of Mucin5AC at mRNA and protein levels ... AR inhibition also decreased IL-13 induced expression of Muc5AC , Muc5B, and SPDEF, and phosphorylation of JAK-1, ERK1/2 and STAT-6
Yu et al., Cell communication & adhesion 2010 : Their results showed that specific knockdown of SPDEF reduced IL-13 induced MUC5AC expression in human airway epithelial cells ... The authors also demonstrated that the repression of STAT6 inhibited expression of SPDEF and MUC5AC induced by IL-13 ... These results show that SPDEF plays a critical role in regulating a transcriptional network mediating IL-13 induced MUC5AC synthesis dependent on STAT6
Tanabe et al., Am J Respir Cell Mol Biol 2011 (Hyperplasia...) : Clarithromycin also dose-dependently decreased MUC5AC mRNA expression induced by IL-13 ( P < 0.001 ), and, at 24 µg/ml, clarithromycin significantly attenuated the amount of MUC5AC protein in cell supernatants ( P < 0.01 )
Tang et al., American journal of rhinology & allergy 2012 (Rhinitis, Allergic, Perennial...) : Both IL-13 and IL-17A significantly promoted MUC5AC mRNA expression in HNECs, and FP treatment was able to significantly inhibit MUC5AC mRNA expression in HNECs induced by IL-13 but not for that induced by IL-17A
Wu et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012 : [ Effects of dexamethasone on IL-13 induced mCLCA3 and Muc5ac expressions in nasal mucosa of rats ] ... To study the effects of dexamethasone on the IL-13 induced mCLCA3 and Muc5ac expressions in nasal mucosa of rats, and the role in mucus secretion of allergic rhinitis
Harrop et al., Exp Lung Res 2013 : This effect was confirmed by using mtCC1-2 cells where addition of TGF-ß ( 2 ) reduced the ability of IL-13/EGF to induce Muc5ac promoter expression in wild-type cells ; however, this decrease was absent in mutant promoter transfected cells
Mata et al., PloS one 2013 (Metaplasia...) : RNO inhibited RSV infection of WD-HBE, prevented the loss of ciliated cells and markers, reduced the increase of MUC5AC and CLCA1 and inhibited the increase of IL-13 , IL-6, IL-8, TNFa and ICAM-1