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IL13 — MMP9
Text-mined interactions from Literome
Meisser et al., Mol Hum Reprod 1999
:
The aim of this study was to determine the
effects of tumour necrosis factor alpha (TNF),
interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of
matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Sun et al., Connect Tissue Res 2003
(Arthritis, Rheumatoid) :
Furthermore, the
induction of the
MMP expression and activities by
interleukin-1 was suppressed by the oscillatory shear
Ma et al., J Immunol 2004
(Inflammation) :
C10/CCL6 neutralization also decreased the ability of
IL-13 to
stimulate the production of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha,
MMP-2 , MMP-9, and cathepsins-K, -L, and -S and the ability of IL-13 to inhibit alpha1-antitrypsin
Giannelli et al., J Interferon Cytokine Res 2006
:
In this study,
interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), commonly elevated in chronic C hepatitis,
stimulate the production of
matrix metalloprotease-9 (MMP-9) by human hepatocytes at a transcriptional and translational level, but the addition of recombinant interferon-alpha2b ( rIFN-alpha2b ) hampers this effect
Purwar et al., J Invest Dermatol 2008
(Dermatitis...) :
IL-13 stimulation of KCs
induced the expression of
MMP-9 but not of MMP-3 or MMP-2 at mRNA level ...
IL-13 induced the release of active
MMP-9 in KCs as detected by an ELISA based assay
Madala et al., J Immunol 2010
(Fibrosis...) :
Instead, we observed marked increases in MMP2 and MMP13 expression, suggesting that Mmp12 was promoting fibrosis by limiting the expression of specific ECM degrading MMPs. Interestingly, like MMP12,
MMP13 expression was highly
dependent on
IL-13 and type II-IL-4 receptor signaling
Saw et al., Am J Pathol 2011
(Fibrosis...) :
Differences between pemphigoid and normal conjunctival fibroblasts with respect to collagen contraction and
MMP secretion in the
presence of
interleukin-13 were also observed
Fujisawa et al., Int J Cancer 2012
(Neoplasm Invasiveness...) :
Mechanistically,
IL-13 enhanced ERK1/2, AP-1 and
MMP activities only in IL-13Ra2 positive cells but not in IL-13Ra2 negative cells
Bailey et al., PloS one 2012
(Crohn Disease...) :
Fibroblasts from intestinal muscle expressed Ra1, phosphorylated STAT6 in
response to
IL-13 , and subsequently down-regulated MMP-2 and TNF-a induced MMP-1 and
MMP-9 synthesis
Alexander et al., Curr Eye Res 1998
:
A phorbol mitogen ( TPA ), and TNF alpha and beta,
interleukin-1 alpha and PDGF BB
stimulate gelatinase B , stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression ; TIMP-2 levels are reduced by TNF but not affected by the other treatments