Gene interactions and pathways from curated databases and text-mining

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IL13 — MMP9

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Ma et al., J Immunol 2004 (Inflammation) : C10/CCL6 neutralization also decreased the ability of IL-13 to stimulate the production of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha, MMP-2 , MMP-9, and cathepsins-K, -L, and -S and the ability of IL-13 to inhibit alpha1-antitrypsin
Giannelli et al., J Interferon Cytokine Res 2006 : In this study, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), commonly elevated in chronic C hepatitis, stimulate the production of matrix metalloprotease-9 (MMP-9) by human hepatocytes at a transcriptional and translational level, but the addition of recombinant interferon-alpha2b ( rIFN-alpha2b ) hampers this effect
Purwar et al., J Invest Dermatol 2008 (Dermatitis...) : IL-13 stimulation of KCs induced the expression of MMP-9 but not of MMP-3 or MMP-2 at mRNA level ... IL-13 induced the release of active MMP-9 in KCs as detected by an ELISA based assay
Madala et al., J Immunol 2010 (Fibrosis...) : Instead, we observed marked increases in MMP2 and MMP13 expression, suggesting that Mmp12 was promoting fibrosis by limiting the expression of specific ECM degrading MMPs. Interestingly, like MMP12, MMP13 expression was highly dependent on IL-13 and type II-IL-4 receptor signaling
Saw et al., Am J Pathol 2011 (Fibrosis...) : Differences between pemphigoid and normal conjunctival fibroblasts with respect to collagen contraction and MMP secretion in the presence of interleukin-13 were also observed
Fujisawa et al., Int J Cancer 2012 (Neoplasm Invasiveness...) : Mechanistically, IL-13 enhanced ERK1/2, AP-1 and MMP activities only in IL-13Ra2 positive cells but not in IL-13Ra2 negative cells
Bailey et al., PloS one 2012 (Crohn Disease...) : Fibroblasts from intestinal muscle expressed Ra1, phosphorylated STAT6 in response to IL-13 , and subsequently down-regulated MMP-2 and TNF-a induced MMP-1 and MMP-9 synthesis
Alexander et al., Curr Eye Res 1998 : A phorbol mitogen ( TPA ), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B , stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression ; TIMP-2 levels are reduced by TNF but not affected by the other treatments