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ARG1 — IL13
Text-mined interactions from Literome
Chang et al., J Immunol 2000
:
The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen activated protein kinase in
IL-13 mediated
arginase I induction in macrophages : its implications in IL-13 inhibited nitric oxide production ... The signaling molecules involved in
IL-13 induced
arginase activation were also determined
Witte et al., J Surg Res 2002
:
The
effect of transforming growth factor beta1 ( TGF-beta1 ),
interleukin-4 (IL-4), lipopolysaccharide, and wound fluid on
arginase activity was also investigated
Zimmermann et al., J Clin Invest 2003
(Asthma...) :
Lung
arginase activity and mRNA expression were strongly
induced by IL-4 and
IL-13 , and were differentially dependent on signal transducer and activator of transcription 6
Lindemann et al., Naunyn Schmiedebergs Arch Pharmacol 2003
:
Glucocorticoid inhibition of interleukin-4 (IL-4) and
interleukin-13 (IL-13) induced up-regulation of
arginase in rat airway fibroblasts ... In conclusion, IL-4 and
IL-13 can
cause a marked up-regulation of
arginase activity in rat airway fibroblasts and these effects can be inhibited by glucocorticoids
Madhankumar et al., Neoplasia (New York, N.Y.) 2004
(Glioma) :
We observed that Lys-105 and
Arg-109 are
critical for
IL13 binding to IL13Ralpha2, indeed
Barksdale et al., Surgery 2004
:
Although isoproterenol, IL-4, IL-10, and
IL-13 individually
induced arginase , significant synergy between the combination of isoproterenol with either TGF-beta or the TH2 cytokines was observed
Yang et al., J Immunol 2006
(Asthma...) :
In the present study, we show that
arginase I expression is also
regulated in the lung in a STAT6 dependent manner by Th2 induced allergic inflammation or by
IL-13 alone ...
IL-13 induced expression of
arginase I correlated directly with increased synthesis of urea and with reduced synthesis of NO
Lotz et al., Immunology 2007
:
Also, IL-4 or
IL-13 led to rapid signal transducer and activator of transcription 6 phosphorylation, diminished inducible NO synthase expression, and
enhanced the antagonistic
arginase 1 activity
Ueta et al., Invest Ophthalmol Vis Sci 2008
(Conjunctivitis...) :
Because
Arg110Gln affects serum
IL-13 , plasma IL-13 levels were also examined
Highfill et al., Blood 2010
(Graft vs Host Disease) :
Exogenous
IL-13 produced an MDSC subset ( MDSC-IL-13 ) that was more potently suppressive and
resulted in
arginase-1 up-regulation
Corraliza et al., Biochim Biophys Acta 1997
:
Moreover,
interleukin 10 which
induces arginase in macrophages is able to increase the cAMP dependent protein kinase A activity