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Boyaka et al., Immunol Res 1999
:
Serum antigen-specific antibody ( Ab ) responses were enhanced when either IL-6 or IL-12 was mucosally administered with a protein antigen, while only IL-12 induced antigen-specific mucosal IgA Ab responses Marinaro et al., J Exp Med 1997
(Hypersensitivity, Delayed) :
Further, serum IgE and S-IgA Ab responses were markedly reduced by parenteral IL-12 Marinaro et al., J Immunol 1999
:
Mucosal secretory IgA responses to oral or nasal vaccines were not affected by intranasal IL-12 Boyaka et al., J Immunol 1999
(Tetanus) :
In summary, both intranasal IL-6 and IL-12 induced serum Abs that protected mice from systemic challenge with TT, whereas only IL-12 induced mucosal S-IgA Ab responses