Everly et al., Virology 2008
(Cell Transformation, Viral) :
LMP1 induces the expression of two members of the family of Id proteins, Id1 and Id3, and affects cell cycle regulation by decreasing the expression of the cyclin dependent kinase inhibitor, p27 , and increasing levels and phosphorylation of cdk2 and Rb
Inoue et al., Nihon rinsho. Japanese journal of clinical medicine 1997
:
However, regulation of the Bcl-xL, Cdk4 and 6 and p27kip-1 expression by LMP1 and the molecular mechanism of LMP1 mediated B cell transformation remain to be elucidated