Hung et al., Nephrol Dial Transplant 2003
(Peritoneal Diseases...) :
At a concentration ( 300 micro g/ml ) that inhibited the collagen gene expression, PTX suppressed the ERK1/2 and p38 ( HOG ) activation by TGF-beta
Chiou et al., Int Immunopharmacol 2004
:
We found that C5a induced, time dependent ( 1 ) ERK1/2 phosphorylation was markedly diminished by PTX, U73122, P13K inhibitors wortmannin and LY294002 and ERK1/2 inhibitor PD98059 ; ( 2 ) Akt phosphorylation was also attenuated by the above inhibitors except PD98059 ; ( 3 ) p38 MAPK phosphorylation was only affected by PTX Zhang et al., Am J Physiol Cell Physiol 2006
:
Pertussis toxin ( PTX ) blocks LPA induced activation of p38 and ERK but only slightly inhibits LPA induced activation of Akt