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EPHA2 — VAV2

Pathways - manually collected, often from reviews:

• NCI Pathway Database EPHA2 forward signaling: VAV2-VAV3 (VAV2/VAV3) → Ephrin A1/EPHA2/VAV2-VAV3 complex (EFNA1-EPHA2-VAV2_VAV3) (modification, collaborate)
  Hunter et al., Mol Cell Biol 2006, Fang et al., J Biol Chem 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EPHA2 forward signaling: VAV2-VAV3 (VAV2/VAV3) → Ephrin A1/EPHA2 complex (EFNA1-EPHA2) (modification, collaborate)
  Hunter et al., Mol Cell Biol 2006, Fang et al., J Biol Chem 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EPHA2 forward signaling: Ephrin A1/EPHA2/VAV2-VAV3 complex (EFNA1-EPHA2-VAV2_VAV3) → Ephrin A1/EPHA2 complex (EFNA1-EPHA2) (modification, collaborate)
  Hunter et al., Mol Cell Biol 2006, Fang et al., J Biol Chem 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EPHA2 forward signaling: None → Ephrin A1/EPHA2/VAV2-VAV3 complex (EFNA1-EPHA2-VAV2_VAV3) (modification, collaborate)
  Hunter et al., Mol Cell Biol 2006, Fang et al., J Biol Chem 2008
  Evidence: mutant phenotype, assay
• NCI Pathway Database EPHA2 forward signaling: RAC1/GDP complex (RAC1) → Ephrin A1/EPHA2/VAV2-VAV3 complex (EFNA1-EPHA2-VAV2_VAV3) (modification, collaborate)
  Hunter et al., Mol Cell Biol 2006, Fang et al., J Biol Chem 2008
  Evidence: mutant phenotype, assay
• NCI Pathway Database EPHA2 forward signaling: Ephrin A1/EPHA2/VAV2-VAV3 complex (EFNA1-EPHA2-VAV2_VAV3) → None (modification, activates) Hunter et al., Mol Cell Biol 2006, Fang et al., J Biol Chem 2008
  Evidence: mutant phenotype, assay
• Reactome Reaction: EPHA2 → VAV2 (reaction) Marignani et al., J Cell Biol 2001, Marston et al., Nat Cell Biol 2003, Cowan et al., Neuron 2005
• Reactome Reaction: EPHA2 → VAV2 (indirect_complex) Marignani et al., J Cell Biol 2001, Cowan et al., Neuron 2005