Gene interactions and pathways from curated databases and text-mining

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CD8A — LCK

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Arcaro et al., J Immunol 2000 : Second, CD8 mediated cross linking of p56lck by multimeric Kd-peptide complexes or by anti-CD8 Ab results in p56lck activation in rafts, from which the abundant phosphatase CD45 is excluded
Luo et al., Mol Cell Biol 1990 : Cross linking of CD8 stimulated tyrosine phosphorylation of p56lck strongly in murine L3 and GA4 cells, slightly in splenocytes, but not detectably in thymocytes
Hurley et al., Science 1989 (Leukemia, T-Cell) : The enzymatic activity of p56lck may therefore be regulated by CD4 and CD8 and be important in antigen induced T cell activation
Irie et al., J Exp Med 1995 : In the CD8 beta+ transfectants, several observations suggested that CD8 beta modifies CD8 alpha associated Lck tyrosine kinase activity : ( a ) in in vitro kinase assays, antibody mediated crosslinking of CD8 alone, or CD8 cross linking with the TCR, resulted in 10-fold greater activation of Lck kinase activity, compared to cells expressing CD8 alpha alpha alone ; ( b ) in vivo, markedly enhanced tyrosine phosphorylation of several intracellular proteins was observed upon CD8 cross linking with the TCR in CD8 alpha beta expressing cells, compared to cells expressing CD8 alpha alpha alone ; and ( c ) Lck association with CD8 alpha was stabilized by the coexpression of CD8 beta
Höllsberg et al., Proc Natl Acad Sci U S A 1995 : CD8 T-cell stimulation with the wild-type peptide antigen led to activation of p56lck kinase activity, interleukin 2 secretion, cytotoxicity, and clonal expansion
Wang et al., J Immunol 1996 : Concomitant to suppression of the kinase by NAD, CD8 mediated transmembrane signaling and p56lck kinase activation are inhibited
Anel et al., Eur J Immunol 1996 : T cell receptor and CD8 dependent tyrosine phosphorylation events in cytotoxic T lymphocytes : activation of p56lck by CD8 binding to class I protein ... These results are consistent with the two-step model for TCR activation of CD8/class I interactions and directly demonstrate that CD8 binding to class I leads to up-regulation of p56lck activity