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PARP6 — RAD51
Text-mined interactions from Literome
Tam et al., Cancer Lett 2009
(Carcinoma, Hepatocellular...) :
RAD001 in combination with cisplatin induced a significant increase in the number of apoptotic cells, downregulated the expression of pro-survival molecules, Bcl-2, survivin and cyclinD1, and
increased the cleavage of
PARP , compared to RAD001 or cisplatin alone
Hegan et al., Proc Natl Acad Sci U S A 2010
(Colonic Neoplasms) :
However, we also report the unexpected finding that disruption of
PARP , itself, either via chemical PARP inhibitors or siRNAs targeted to PARP-1, can inhibit HDR by
suppressing expression of BRCA1 and
RAD51 , key factors in HDR of DNA breaks