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MAPK6 — TRAF6
Text-mined interactions from Literome
Pullen et al., J Biol Chem 1999
:
In contrast, p38
mitogen activated protein kinase activation was primarily
dependent upon
TRAF6 binding
Schultheiss et al., EMBO J 2001
(Cell Transformation, Viral...) :
In TRAF6-knockout fibroblasts, significant induction of p38
MAPK by LMP1 is
dependent on the ectopic expression of
TRAF6
Li et al., American journal of physiology. Renal physiology 2002
:
TRAF6 , in turn,
activates SAPK/JNK and p38
MAPK phosphorylation, which in turn stimulates IL-8 and MCP-1 production in these cells
Matsuyama et al., J Immunol 2003
(MAP Kinase Signaling System) :
Transfection of differentiated DDR1b overexpressing THP-1 cells with dominant negative TRAF6 completely abrogated DDR1b mediated p38 MAPK phosphorylation, indicating a critical
role of
TRAF6 in DDR1b mediated p38
MAPK activation
Mason et al., Infect Immun 2004
:
TRAF6 dependent
mitogen activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii
Horie et al., Microbes Infect 2007
(HIV Infections) :
TRAF activation of C/EBPbeta ( NF-IL6 ) via p38
MAPK induces HIV-1 gene expression in monocytes/macrophages
Funakoshi-Tago et al., Cytokine 2009
:
On the other hand,
TRAF6 deficiency did not
affect the TNFalpha induced activation of
mitogen activated protein ( MAP ) kinases , ERK, JNK, and p38
Avila et al., Innate Immun 2012
:
Lyn kinase controls TLR4 dependent IKK and
MAPK activation
modulating the activity of
TRAF-6/TAK-1 protein complex in mast cells