◀ Back to FOXO3
BNIP3 — FOXO3
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
BNIP3
→
FOXO3
(directlyIncreases, BNIP3 Activity)
Evidence: Following its dephosphorylation, FOXO3 translocates into the nucleus (Fig. 3A) and upregulates multiple autophagy-related genes such as ULK2, Beclin 1, VPS34, BNIP3 and BNIP3L, ATG12, ATG4B, LC3, and GABARAPL1 (Mammucari et al., 2007).
Text-mined interactions from Literome
Mammucari et al., Cell Metab 2007
(Muscular Atrophy) :
FoxO3 controls the transcription of autophagy related genes, including LC3 and Bnip3, and
Bnip3 appears to
mediate the effect of
FoxO3 on autophagy
Nath et al., J Clin Invest 2010
:
Kume et al. demonstrated that caloric restriction protected the aging kidney by preserving renal Sirt1 expression, the latter deacetylating
forkhead box O3a (FOXO3a) ,
inducing Bnip 3 , and promoting mitochondrial autophagy
Xu et al., Genes Dev 2011
:
This autophagic response is caused by
FoxO induced expression of
Bnip3 that displaces the autophagic effector Beclin-1 from inactive Bcl-XL complexes
Reed et al., FASEB J 2012
(Cachexia...) :
Expression of DN
FoxO inhibited the increased mRNA levels of atrogin-1, MuRF1, cathepsin L, and/or
Bnip3 and inhibited muscle fiber atrophy during cancer cachexia and sepsis