Yamaguchi et al., J Biol Chem 2007
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The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha) Sun et al., Cell Signal 2010
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In addition, overexpression of a catalytically inactive USP11 mutant partially inhibits TNFalpha- and IKKbeta induced NF-kappaB activation, suggesting that USP11 also exerts a non-catalytic function in its negative regulation of TNFalpha mediated NF-kappaB activation