◀ Back to TNF
TNF — TNFSF13B
Text-mined interactions from Literome
Scapini et al., Blood 2005
(Arthritis, Rheumatoid) :
We show that CXCL1/GROalpha, CXCL8/IL-8, C5a, immune complexes,
tumor necrosis factor-alpha (TNF-alpha), leukotriene B4, N-formyl-methionyl-leucyl-phenylalanine ( fMLP ), and lipopolysaccharide (LPS), which by themselves do not
induce BLyS de novo synthesis, act as potent secretagogues for BLyS, which is mainly stored in Golgi related compartments within G-CSF treated neutrophils, as determined by immunogold electron microscopy
Assi et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid...) :
Of the various cytokine stimuli, only
TNFalpha triggered release of
BLyS from the neutrophil membrane ... These findings indicate that as neutrophils enter the site of inflammation, they release surface expressed
BLyS in a
TNFalpha dependent manner, and thus may contribute to local stimulation of autoimmune B cell responses
Alsaleh et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid) :
In contrast to IFNgamma, neither
TNFalpha , LPS, BLP, nor CpG
induced the de novo synthesis and release of
BAFF by FLS ... Moreover, we found that IFNgamma induced
BAFF synthesis is inhibited by simultaneous
stimulation with either TLR ligands or
TNFalpha
Mavragani et al., Arthritis Rheum 2007
(Sjogren's Syndrome) :
To address the hypothesis that
tumor necrosis factor blockade can
result in increased levels of interferon-alpha ( IFNalpha ) and
BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients
Reyes et al., Cytokine 2008
(Arthritis, Rheumatoid) :
Therefore, Dex is a potent inhibitor of constitutive and
TNF-alpha induced
BAFF expression in FLS-RA
Kim et al., Exp Mol Med 2009
(Inflammation...) :
BAFF expression was
augmented by
TNF-alpha treatment and was decreased by rosiglitazone treatment
Pyrpasopoulou et al., J Interferon Cytokine Res 2012
(Arthritis, Rheumatoid) :
Moreover,
tumor necrosis factor (TNF) blockade did not appear to
affect BAFF levels in either seropositive or seronegative RA patients, despite the association of anti-TNF treatment with the development of autoantibodies and the known anti-apoptotic effects of BAFF
Lee et al., Int Immunopharmacol 2013
:
Our results demonstrate for the first time that VEGF mediated angiogenesis in RA could be controlled by
TNF-a induced
BAFF expression through c-Fos ... Data suggest that
TNF-a induced
BAFF expression and BAFF mediated VEGF expression in synovium may cooperate to maintain the capacity of such cells to protect B cells from apoptosis and the supply of nutrients and oxygen in inflammatory microenvironments