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SMPD3 — TNF
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF)
→
Neutral sphingomyelinase II (SMPD3)
(modification, activates)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
Neutral sphingomyelinase II (SMPD3)
(modification, activates)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Clarke et al., J Biol Chem 2007
(Lung Neoplasms) :
These data reveal p38 MAPK as an upstream regulator of nSMase2 and indicate a role for
nSMase2 in pro-inflammatory responses
induced by
TNF-alpha as a regulator of adhesion proteins
Clarke et al., Mol Pharmacol 2008
(Lung Neoplasms) :
Here, we report a role for protein kinase C ( PKC ) in mediating
TNF induced translocation of
nSMase2 from the Golgi to the plasma membrane ( PM ) ... Pharmacological inhibition of PKCs prevented
TNF stimulated
nSMase2 translocation to the PM in A549 cells
Philipp et al., Proc Natl Acad Sci U S A 2010
:
In yeast, the N terminus of EED binds to the catalytic domain of nSMase2 as well as to RACK1, a protein that modulates the
activation of
nSMase2 by
TNF in concert with the TNF receptor 1 (TNF-R1) associated protein FAN ... In mammalian cells,
TNF causes endogenous EED to translocate from the nucleus and to colocalize and physically interact with both endogenous
nSMase2 and RACK1 ... After knockdown of EED by RNA interference, the
TNF dependent activation of
nSMase2 is completely abrogated, identifying EED as a protein that both physically and functionally couples TNF-R1 to nSMase2, and which therefore represents the `` missing link '' that completes one of the last unresolved signaling pathways of TNF-R1