◀ Back to TNF

SETBP1 — TNF

Text-mined interactions from Literome

Yan et al., Infect Immun 1999 : In this study, we have used mixed cultures of human peripheral blood monocytes and lymphocytes to investigate biochemical events controlling SEB induction of TNF-alpha ... TNF-alpha production induced by SEB in mixed cultures is more closely associated with T cells than with monocytes : ( i ) a TCR-binding-site mutant of SEB ( N23F ) is less active in TNF-alpha induction than an MHC class II receptor-binding-site mutant ( F44R ), and ( ii ) flow cytometric analysis indicated that SEB induced TNF-alpha production in T cells but not in monocytes ... Pretreatment of cells with inhibitors of signal transduction pathways was employed to further define events in SEB induced TNF-alpha production ... Neither protein kinase A inhibitors nor two protein tyrosine kinase inhibitors altered SEB induced TNF-alpha production ... In contrast, SEB induced protein kinase C ( PKC ) translocation, and pretreatment of cultures with inhibitors of PKC blocked TNF-alpha induction ... Alteration of levels of diacylglycerol ( DAG ), an activator of PKC, by treatment with inhibitors of phospholipase C or DAG kinase also altered SEB induced TNF-alpha production ... These data suggest that PKC activation plays a critical role in SEB induced TNF-alpha production in human T cells
Pang et al., Infect Immun 2000 (Shock, Septic) : MAb5 was found to partially inhibit SEB induced T-cell mitogenesis ( 63 % ) and tumor necrosis factor alpha (TNF-alpha) secretion ( 70 % ) in human peripheral blood mononuclear cells ( PBMC ) in a dose dependent manner, while an isotypic anti-TSST-1 monoclonal antibody showed no effect ... SEB peptide ( 83 ) DVFGANYYYQ ( 92 ) was synthesized and found to also inhibit SEB induced mitogenesis and TNF-alpha secretion in human PBMC
Schümann et al., Immunol Lett 2000 (Drug-Induced Liver Injury) : PEA/LPS-, PEA/SEB- or PEA/rmuTNF induced liver injury was mediated by both TNF receptors (TNFRs) , i.e. TNFR1 and TNFR2
Anderson et al., Clin Immunol 2001 (Disease Susceptibility...) : The SEB induced TNF response in vitro and in vivo was stronger in resistant B10.BR mice than in susceptible C3H/HeJ mice
Komisar et al., Toxicol Pathol 2001 (Shock, Septic) : All monkeys made IL-2, TNF , and IFN-gamma in response to SEB
Kawasaki et al., Can J Anaesth 2001 : To investigate the efficacy of S ( + ) -ketamine and R ( - ) -ketamine on staphylococcal enterotoxin B (SEB) induced tumour necrosis factor (TNF)- , interleukin (IL)-6, and IL-8 production in human whole blood in vitro ... Ketamine isomers significantly suppressed SEB induced TNF- production at concentrations exceeding 50 microM ... This study demonstrated that ketamine isomers suppressed SEB induced TNF- , IL-6, and IL-8 production in human whole blood
Yasuda et al., J Endotoxin Res 2002 (Shock) : Peritoneal macrophages from C3H/HeJ mice did not produce TNF-alpha in vitro in response to SEB or LPS
Hisano et al., Arch Dermatol Res 2003 (Dermatitis, Atopic) : Polyphenon inhibited the lethal toxicity of SEB and the SEB induced production of TNF-alpha , IFN-gamma and IL-4 following its intraperitoneal administration to BALB/c mice ... Furthermore, EGCg inhibited SEB induced TNF-alpha and IFN- gamma production and IL-2, IFN-gamma, IL-10 and IL-12 p40 mRNA expression in human PBMCs from normal donors in a dose dependent manner
Haraguchi et al., J Leukoc Biol 1992 : We investigated the influence of CKS-17, a synthetic heptadecapeptide that corresponds to a highly conserved domain of the immunosuppressive retroviral envelope protein p15E, on staphylococcal enterotoxin B (SEB) induced TNF-alpha gene expression in human peripheral blood mononuclear cells and highly purified human monocyte preparations, as well as the production of TNF-alpha protein, using human peripheral blood mononuclear cells ... RNA hybridization studies show that CKS-17 inhibits SEB induced TNF-alpha mRNA accumulation in human peripheral blood mononuclear cells and human monocytes ... CKS-17 is also shown to be highly suppressive for SEB induced production of TNF-alpha proteins
Droin et al., Mol Cell Biol 2003 : We demonstrate here that superantigen Staphylococcus enterotoxin B (SEB) induced a dramatic upregulation of FasL, TRAIL, and TNF mRNA expression and function in IEC from BALB/c and C57BL/6 mice
Kawasaki et al., Anesth Analg 2004 : We designed this study to investigate the effects of local anesthetics on monocyte mCD14 and human leukocyte antigen ( HLA ) -DR expression and lipopolysaccharide (LPS) induced or staphylococcal enterotoxin B (SEB) induced tumor necrosis factor (TNF)-alpha production ... The effects of local anesthetics on LPS- or SEB induced TNF-alpha production were determined by using an enzyme linked immunosorbent assay ... Local anesthetics showed no effect on LPS- or SEB induced TNF-alpha production in human whole blood
Ogata et al., Anesth Analg 2004 : LPS, SEB , and both E. coli and S. aureus induced TNF , IL-6, and IL-8 in human whole blood ... TCV-309 significantly inhibited the production of TNF , IL-6, and IL-8 induced by LPS, SEB , and bacteria
Greeneltch et al., Brain Behav Immun 2004 (Shock, Septic) : Naltrexone significantly inhibited the production of TNF-alpha induced by LPS, but not SEB in vivo
Watson et al., Cell Immunol 2005 : Pretreatment or co-treatment of human PBMC or murine lymphnode cells with EGCG significantly reduced SEB induced proliferation and IL-2, IFNgamma, and TNFalpha production
Amat et al., Br J Pharmacol 2006 (Arthritis) : Compound J-113863 was tested in collagen induced arthritis ( CIA ) and three models of acute inflammation ; Staphylococcus enterotoxin B (SEB) induced interleukin-2 (IL-2), delayed-type hypersensitivity ( DTH ) response, and lipopolysaccharide (LPS) induced tumour necrosis factoralpha (TNFalpha) production
Khan et al., J Leukoc Biol 2008 : SEB induced signaling in macrophages leads to biphasic TNF-alpha
Desouza et al., Eur J Pharmacol 2009 : Increased production of TNF-alpha and IL-1 in alveolar macrophages was observed in response to SEA and SEB
Krakauer et al., Mediators Inflamm 2010 (Hypothermia...) : SEB induced low levels of TNFalpha , IL-1, IFNgamma, MIP-2, and LPS synergized with SEB in the expression of these cytokines and that of IL-6 and MCP-1
Xie et al., Mol Nutr Food Res 2011 (Inflammation) : SEB significantly inhibited LPS induced mRNA expression and protein levels of TNF-a and IL-6
Prager et al., J Neuroimmune Pharmacol 2013 : However, only treatment with LPS, but not SEB , enhanced amygdaloid IL-1ß and TNF-a mRNA expression
Florquin et al., J Exp Med 1994 (Shock, Septic) : In vitro experiments indicated that NO synthase (NOS) inhibition by N-nitro-L-arginine methyl ester ( L-NAME ) enhanced IFN-gamma and TNF production by splenocytes in response to SEB
Sperber et al., Clin Diagn Lab Immunol 1995 : In IEL, SEE induced no IL-2, IL-4, or gamma interferon but produced IL-6 and TNF, while SEB stimulation resulted in no IL-2 or gamma interferon but did result in detectable IL-4, IL-6, and TNF
Matsuyama et al., Eur J Immunol 1993 : Monoclonal antibodies directed against HLA-DR and -DQ abolished the SEB induced expression of both the IL-1 beta and TNF-alpha genes, suggesting that the HLA class II molecules mediated the gene expression
Nagaki et al., Gastroenterology 1994 (Shock) : SEB induced the production of TNF-alpha and IFN-gamma in a dose dependent manner from splenic mononuclear cells in vitro ... The results show that SEB contributes to lethal shock associated with severe hepatic injury in GalN sensitized mice and suggest that TNF-alpha and IFN-gamma produced in response to SEB may be mediators of the lethal toxicity and hepatotoxicity of SEB
Astiz et al., J Lab Clin Med 1996 (Sepsis...) : In response to SEB , patients with sepsis and patient with septic shock demonstrated significantly decreased release of TNF-alpha and IL-1beta
Darville et al., Infect Immun 1997 : In contrast, pretreatment of SEB with 0.1 mg of IVIG per ml resulted in significant ( greater than 50 % ) inhibition of SEB induced TNF-alpha secretion at 24, 48, 72, and 96 h ( P < 0.05 for TNF-alpha levels induced by SEB alone versus SEB pretreated with IVIG at all time points )
Tiegs et al., Acta Gastroenterol Belg 1997 (Autoimmune Diseases...) : Anti-CD3 mAb as well as SEB or Con A induced the release of systemic tumor necrosis factor (TNF) , interferon gamma (IFN gamma), and various other cytokines
Baum et al., Eur J Appl Physiol Occup Physiol 1997 : Production of interleukin (IL)-1beta, IL-6 and tumour necrosis factor (TNF)-alpha were induced with lipopolysaccharides (LPS), and that of IL-2 and interferon (IFN)-gamma with staphylococcal enterotoxin B (SEB) and phytohaemagglutinin ( PHA )
Baum et al., Cell Immunol 1998 : We conclude that TNF-alpha , not CD154, plays the major role in SEB-driven , CD4 ( + ) T cell induced endothelial cell activation in vitro
Soltys et al., Infect Immun 1999 : In vitro stimulation of lymphocytes isolated from soluble beta-glucan treated mice with lipopolysaccharide (LPS) resulted in enhanced production of interleukin-6 (IL-6) and suppressed production of tumor necrosis factor alpha (TNF-alpha), while stimulation of these cells with staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin 1 ( TSST-1 ) resulted in enhanced production of gamma interferon ( IFN-gamma ) and suppressed production of IL-2 and TNF-alpha compared to that in cells isolated from untreated mice ... In vitro stimulation of monocytes isolated from soluble beta-glucan treated mice with LPS also resulted in suppressed TNF-alpha production, while stimulation of these cells with SEB or TSST-1 resulted in suppressed IL-6 and TNF-alpha production compared to that in cells isolated from untreated mice
Schafer et al., J Immunol 1999 : TNF-alpha production by peripheral T cells in response to SEB and anti-CD28 mAb correlated more closely with ERK activity than with p38 activity