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SAA1 — TNF

Text-mined interactions from Literome

Furlaneto et al., Biochem Biophys Res Commun 2000 : This study focuses on the effect of AI, SAA , and HDL from healthy ( N-HDL ) and acute phase individuals ( AP-HDL ) on the release of TNF-alpha , IL-1beta, and IL-8 by human blood neutrophils
Thorn et al., Amyloid 2002 : The Saa1 and Saa2 promoters are strongly induced by IL-6, with synergistic upregulation of Saa2, but not of Saa1, by IL-1 or TNF
Ribeiro et al., Mediators Inflamm 2003 : In a previous study, we reported that SAA induces the release of tumor necrosis factor-alpha , interleukin (IL)-1beta and IL-8 from human blood neutrophils
Smith et al., Clin Exp Immunol 1992 : IL-1 beta was the more potent inducer for SAA production, but for CRP production IL-1 alpha and IL-1 beta were equivalent ; ( iii ) prednisolone enhances the production of SAA by HepG2 cells, but does not enhance the production of CRP ; ( iv ) TNF-alpha in the presence or absence of IL-6 and/or prednisolone did not induce the production of SAA or CRP by HepG2 cells
Hagihara et al., Biochem Biophys Res Commun 2004 : Either IL-6 and IL-1beta or IL-6 and TNFalpha , but not IL-1beta and TNFalpha, induced the synergistic induction of SAA1 and SAA2 genes
Son et al., Endocrinology 2004 : Tumor necrosis factor-alpha induces serum amyloid A3 in mouse granulosa cells
Hatanaka et al., Immunol Lett 2004 : Our findings indicate that SAA stimulates the rapid expression and release of TNF-alpha from cultured human blood neutrophils
Thorn et al., Scand J Immunol 2004 : Here, we examine the roles of TNF-alpha , interleukin-6 (IL-6) and GCs on the transcriptional regulation of the two human A-SAA genes ( SAA1 and SAA2 ) and show that these stimuli have different effects on the SAA1 and SAA2 promoters in HepG2 hepatoma and KB epithelial cell lines ... The TNF-driven induction of SAA1 , but not that of SAA2, can be enhanced by GCs in both cell lines, whereas GCs alone can upregulate SAA1 only in epithelial cells
Niemi et al., Biochim Biophys Acta 2006 : SAA induced dose dependent production of TNF-alpha and IL-1 beta in HMC-1 cells
Ganapathi et al., J Immunol 1991 (Carcinoma, Hepatocellular...) : TNF-alpha alone had no significant effect on synthesis of either SAA or CRP, but the combination of IL-6 plus TNF-alpha led to substantial induction of SAA
Lee et al., Mol Pharmacol 2006 : We found that serum amyloid A stimulated the production of tumor necrosis factor (TNF)-alpha and interleukin (IL)-10, which are proinflammatory and anti-inflammatory cytokines, respectively, in human monocytes
Dowton et al., Pediatr Res 1991 (Acute-Phase Reaction) : Studies of immature hamsters after birth show that the responses of CRP and SAA genes to lipopolysaccharide, tumor necrosis factor , IL-1, and IL-6 are reduced when compared with induction of mRNA accumulation for these acute phase reactants in adult animals
Kho et al., Biosci Biotechnol Biochem 2008 : TNFalpha treatment of HC11 cells also induced expression of SAA genes, and the effect on SAA1 and SAA2 expression was suppressed by treatment with MG132, and in cells transfected with a dominant negative mutant form of IkappaBalpha
Song et al., Atherosclerosis 2009 (Acute Coronary Syndrome...) : This study examined SAA induction of TF and tumour necrosis factor-alpha (TNF) in PBMC from patients with CAD and in monocytoid THP-1 cells ... Unlike CRP, SAA induced TF and TNF in THP-1 cells ... SAA induced TNF was dose-dependently inhibited by HDL ... Importantly, SAA induced TNF levels ( ELISA ) were much higher in patients with ACS than SA or controls ( ACS 211+/-41, SA 108+/-16, controls 73+/-11 pg/mL, with SAA 250 ng/mL, P=0.001 ACS vs. controls or P=0.013 ACS vs. SA across the dose range )
Sandri et al., Immunol Lett 2008 : In previous studies, we demonstrated that SAA stimulated the production of TNF-alpha , IL-1beta, IL-8, NO, and ROS by neutrophils and/or mononuclear cells
Poitou et al., J Clin Endocrinol Metab 2009 (Obesity, Morbid) : IL-1beta, TNF-alpha , and human AT macrophage conditioned medium significantly induced A-SAA secretion ( from 2.6 to 7.6 fold ) in hMADS cells
Yoshizaki et al., Yakugaku Zasshi 2009 (Autoimmune Diseases...) : The results, indicated that the IL-6 signal was essential though the activation of STAT3 for the induction and augmentation of CRP or SAA by the associated stimulation with TNF-alpha or IL-1
Son et al., Endocrinology 2010 : Because ovulation is an inflammatory reaction and TNF specifically induces serum amyloid A3 (SAA3) in mouse granulosa cells, the effect of cAMP on TNF induced SAA3 promoter activity, mRNA and protein was investigated
Toussaint et al., Toxicol In Vitro 1993 : LPS and TNF-alpha increased the secretion of serum amyloid A (SAA) in hamster hepatocytes
Dong et al., Mol Med 2011 (Atherosclerosis...) : With increased SAA levels, the plasma levels of interleukin-6 and tumor necrosis factor-a were significantly increased
Connolly et al., Arthritis Rheum 2012 (Arthritis, Rheumatoid...) : Acute-phase serum amyloid A regulates tumor necrosis factor a and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy
Ganapathi et al., J Immunol 1988 : These results indicate that human SAA and CRP are induced in Hep 3B cells by products of activated monocytes but not by IL-1 beta, TNF-alpha , or some hepatocyte stimulating factor preparations and that a group of heterogeneous mechanisms are involved in the induction of the various human APP
Ghezzi et al., Lymphokine Res 1988 : Dexamethasone modulation of LPS, IL-1, and TNF stimulated serum amyloid A synthesis in mice ... Exogenous IL-1 and TNF induce SAA synthesis in vivo and in vitro, while exogenous IL-6 is a far less potent stimulus of in vivo SAA gene expression ... However, DEX did not reduce, but rather potentiated, IL-1 and TNF stimulated SAA production, indicating that these monokines do not require macrophage products to mediate their in vivo SAA inducer activity
Sipe et al., Lymphokine Res 1987 : Tumor necrosis factor/cachectin is a less potent inducer of serum amyloid A synthesis than interleukin 1
Gabay et al., Clin Exp Immunol 1995 (Carcinoma, Hepatocellular) : In the hepatoma cell line, IL-1 beta and/or TNF-alpha had synergistic effects with IL-6 on the production of CRP and SAA