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PRKCD — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Mohamed et al., Biochem J 2002
(MAP Kinase Signaling System) :
Inhibition in HeLa cells of caspase function by pharmacological inhibitors or the expression of CrmA ( cytokine response modifier A ), a viral modifier protein, blocks
TNF induced apoptosis or caspase dependent
protein kinase Cdelta and poly ( ADP-ribose ) polymerase protein degradation
Kilpatrick et al., Am J Physiol Cell Physiol 2002
:
In adherent neutrophils,
TNF-alpha triggers association of both
protein kinase C (PKC)-delta and phosphatidylinositol (PI) 3-kinase with the p60TNFR
Satoh et al., Gastroenterology 2005
(Acute Disease...) :
Furthermore, with antisense transfections, we showed that
protein kinase C delta and, but not proline-rich tyrosine kinase 2,
mediate tumor necrosis factor alpha induced nuclear factor-kappaB activation
Ramana et al., Endocrinology 2007
:
High glucose ( HG ) -induced
TNF-alpha release was specifically
inhibited by
protein kinase C (PKC)-delta inhibitor ( Rottlerin ; EMD Biosciences, San Diego, CA ), but not PKC-beta2 inhibitor ( CGP53353 ; Tocris Cookson Inc., Ellisville, MO ), indicating the possible involvement of PKC-delta in HG signaling
Reddy et al., Endocrinology 2009
(Inflammation) :
Inhibition of
protein kinase C (PKC)-delta by rottlerin
prevented HG-induced TACE activation and the accumulation of unprocessed
TNF-alpha