Gene interactions and pathways from curated databases and text-mining

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NPY — TNF

Text-mined interactions from Literome

Hernanz et al., Regul Pept 2003 (Arthritis, Rheumatoid...) : In the present study, we have investigated the in vitro effect of calcitonin related peptide ( CGRP ), neuropeptide Y (NPY) , substance P ( SP ) and vasoactive intestinal peptide (VIP) at concentrations of 10 ( -8 ), 10 ( -9 ) and 10 ( -10 ) M on the production of different proinflammatory cytokines or chemokines such as IL-1beta, IL-6 and TNFalpha by peripheral whole blood cells from patients with rheumatoid arthritis, as well as from osteoarthritis patients studied as a control group without immunoinflammatory background
Puerto et al., J Neuroimmunol 2005 : The present work deals with the in vitro effects of norepinephrine and neuropeptide Y , separately and jointly, on functions such as lymphoproliferation, NK activity, and IL-2 and TNF-alpha release of peritoneal leucocytes from adult ( 24+/-2 weeks ), old ( 72+/-2 weeks ) and very old ( 128+/-2 weeks ) mice
Zhou et al., J Neuroimmunol 2013 (MAP Kinase Signaling System) : In the present work, we have evaluated the effects of NPY on the release of TNF-a , IL-1ß, IL-6 and HMGB1 mediators in peritoneal macrophages ... Our results demonstrate for the first time that NPY can directly induce active HMGB1 release and cytoplasmic translocation, while the production of TNF-a , IL-1ß and IL-6 is not affected
Hernanz et al., J Neuroimmunol 1996 : Differential effects of gastrin releasing peptide, neuropeptide Y , somatostatin and vasoactive intestinal peptide on interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects ... In the present study, we have investigated the effect in vitro of gastrin releasing peptide ( GRP, 10 ( -10 ) M ), neuropeptide Y ( NPY, 10 ( -10 ) M ), somatostatin ( 10 ( -10 ) M ) and vasoactive intestinal peptide ( VIP, 10 ( -9 ) M ) on the production of IL-1 beta, IL-6 and TNF alpha by peripheral whole blood cells from healthy young and old people ... The TNF alpha production was stimulated by NPY and somatostatin in young subjects, and by NPY , somatostatin and VIP in old ones, whereas GRP produced a decrease of TNF alpha in young persons