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MSK32 — TNF
Text-mined interactions from Literome
Gustin et al., Am J Physiol Cell Physiol 2004
(MAP Kinase Signaling System) :
From among the kinases that can activate CREB, we found that downstream of p38 MAPK,
MSK1 is
activated by
TNF to promote CREB activation
Sury et al., Free Radic Biol Med 2006
(MAP Kinase Signaling System) :
Supporting this notion, cotreatment with NAC inhibited the
TNF-alpha induced rise in
MSK1 and MSK2 kinase activity, while siRNA knock-down experiments showed that MSK2 is the predominant isoform involved in TNF-alpha induced ET-1 upregulation
Olson et al., Infect Immun 2007
:
The repression of
MSK1 expression with small interfering RNA
results in reduced RelA phosphorylation and a significant decrease in the production of
TNF-alpha in response to B. burgdorferi lysates
Jamaluddin et al., Cell Signal 2007
:
Interestingly, antioxidant treatment selectively inhibited
TNF-alpha induced catalytic activity of cAMP dependent protein kinase A ( PKAc ) but not
mitogen-stress related kinase-1 ( MSK1 ) , kinases known to phosphorylate RelA at Ser ( 276 )
Defer et al., J Biol Chem 2007
(Calcium Signaling...) :
Together with cPLA(2) redistribution and AA release,
TNFalpha induced a time dependent phosphorylation of ERK,
MSK1 , PKCzeta, CaMKII, and phospholamban on the threonine 17 residue
Yang et al., Free Radic Biol Med 2011
:
Desialylation completely abolished darbepoetin alfa 's inhibitory effects on
TNF-a induced ROS accumulation,
MSK1 activation , and ET-1 gene expression, without affecting its stimulation of STAT5 activity
Deak et al., EMBO J 1998
:
In HeLa, PC12 and SK-N-MC cells, PD 98059 and SB 203580 are both required to suppress the
activation of
MSK1 by
TNF , NGF and FGF, respectively, because these agonists activate both the MAPK/ERK and SAPK2/p38 cascades