Gene interactions and pathways from curated databases and text-mining

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MAP3K7 — TNF

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Sakurai et al., J Biol Chem 1999 : Furthermore, tumor necrosis factor-alpha activated endogenous TAK1, and the kinase negative TAK1 acted as a dominant negative inhibitor against tumor necrosis factor-alpha induced NF-kappaB activation
Cheung et al., EMBO J 2003 : The activation of TAK1 by TNF-alpha , IL-1 or osmotic shock was also enhanced in embryonic fibroblasts from SAPK2a/p38alpha-deficient mice, while incubation of these cells with SB 203580 had no effect
Singhirunnusorn et al., J Biol Chem 2005 : Immunoblotting with a novel phospho-TAK1 antibody revealed that TNF-alpha significantly induced the phosphorylation of endogenous TAK1 at Thr-187, and subsequently the phosphorylated forms of TAK1 rapidly disappeared ... Furthermore, SB203580 and p38alpha small interfering RNA enhanced TNF-alpha induced Thr-187 phosphorylation as well as TAK1 kinase activity, indicating that the phosphorylation is affected by p38alpha/TAB1/TAB2 mediated feedback control of TAK1
Choo et al., Int J Cancer 2006 (Colonic Neoplasms...) : Activation of endogenous TAK1 , a mitogen activated protein kinase ( MAP3K ) regulating the JNK and p38 MAPK pathways, was induced rapidly by TNF-alpha , and co-transfection of TAK1 with its activator protein TAB1 stimulated activation of JNK and p38 MAPKs, which led to activation of the transcription factor AP-1
Bertelsen et al., Cell Signal 2007 : In this study, a critical role for TAK1 in IL-1alpha or TNFalpha stimulated MAPK and NFkappaB activation was confirmed by inhibition of the nuclear accumulation of NFkappaB p65 and phosphorylated forms of c-Jun and p38 following siRNA mediated TAK1 silencing
Sethi et al., Blood 2007 (Neoplasm Invasiveness...) : Recent studies indicate that TNF induced IKK activation requires activation of TAK1 , and we indeed found that celastrol inhibited the TAK1 induced NF-kappaB activation
Nakajima et al., EMBO J 2006 : Moreover, c-FLIPL directly interacts with a JNK activator, MAP kinase kinase (MKK)7, in a TNFalpha dependent manner and inhibits the interactions of MKK7 with MAP/ERK kinase kinase 1, apoptosis-signal regulating kinase 1, and TGFbeta activated kinase 1
Windheim et al., Biochem J 2007 : We also show that MDP activates ERK1 ( extracellular-signal regulated kinase 1 ) /ERK2 and p38alpha MAPK in human peripheral-blood mononuclear cells and that the activity of both MAPKs and TAK1 are required for MDP induced signalling and production of IL-1beta and TNFalpha in these cells
Sung et al., Mol Pharmacol 2007 : Fisetin also inhibited TNF induced TAK1 and receptor interacting protein activation, events that lie upstream of IKK activation
Shin et al., Biochim Biophys Acta 2009 : Cross interference with TNF-alpha induced TAK1 activation via EGFR mediated p38 phosphorylation of TAK1 binding protein 1 ... The inducible phosphorylation of TAB1 interfered with a response of EGF treated cells to TNF-alpha induced TAK1 activation, which led to the reduction of NF-kappaB activation ... Collectively, these results demonstrated that EGFR activation interfered with TNF-alpha induced TAK1 activation via p38 mediated phosphorylation of TAB1
Taniguchi et al., Mol Cell Endocrinol 2009 (Endometriosis) : TNFalpha augmented the phosphorylation of TAK1
Geurts et al., Rheumatology (Oxford) 2011 (Arthritis, Rheumatoid) : In general, TAK1 crucially regulates IL-1 and TNF signalling in fibroblasts
Avila et al., Innate Immun 2012 : Our results indicate that Lyn plays a positive role in TLR4 induced production of TNF-a in MCs controlling the activity of the TRAF-6/TAK-1 protein complex
Gardner et al., Am J Pathol 2012 (Bronchiolitis Obliterans) : TGF-ß activated kinase 1 (TAK1) is activated by both TGF-ß1 and TNF-a , activating both nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen activated protein kinase signaling pathways