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HSF1 — TNF

Text-mined interactions from Literome

Singh et al., J Biol Chem 2000 (Fever) : These data suggest that partial activation of HSF-1 during exposure to febrile, sub-heat shock temperatures may block TNFalpha transcription by binding to its proximal promoter or 5'-untranslated region
Singh et al., J Biol Chem 2002 : Mutational inactivation of this site blocks the inhibitory effect of overexpressed HSF-1 on activity of the minimal TNFalpha promoter ( -85/+138 ) in Raw 264.7 murine macrophages, identifying this site as an HSF-1 dependent repressor ... This suggests that HSF-1 might repress TNFalpha transcription through redundant mechanisms, some of which might not require high affinity binding of HSF-1
Schett et al., Cell Death Differ 2003 (MAP Kinase Signaling System) : TNFalpha caused transient downregulation of HSF1 activation and hsp70 synthesis, leading to increased sensitivity to heat induced apoptosis
Mandrekar et al., J Leukoc Biol 2008 (Inflammation) : Heat shock proteins ( hsps ) and the heat shock transcription factor-1 ( HSF-1 ) induced by oxidative stress regulate NF-kappaB activation and TNF-alpha gene expression in monocytes and macrophages
Cooper et al., Am J Physiol Cell Physiol 2010 (Fever) : Using HSF1-null mice, we confirmed that HSF1 is required for FRT induced repression of TNF-alpha in vitro by LPS stimulated bone marrow derived macrophages and in vivo in mice challenged intratracheally with LPS