◀ Back to TNF

HMGB3 — TNF

Text-mined interactions from Literome

Yu et al., Shock 2006 : Similarly, in primary human macrophages, HMGB1 induced TNF release is dose-dependently inhibited by anti-TLR4 antibodies ... In primary macrophages from knockout mice, HMGB1 activates significantly less TNF release in cells obtained from MyD88 and TLR4 knockout mice as compared with cells from TLR2 knockout and wild-type controls
Voll et al., Isr Med Assoc J 2008 (Autoimmune Diseases...) : Upon stimulation with lipopolysaccharides or tumor necrosis factor-alpha , HMGB1 is secreted from certain cells such as monocytes/macrophages and fosters inflammatory responses
Xu et al., Am J Physiol Heart Circ Physiol 2011 (Heart Injuries...) : However, inhibition of HMGB1 attenuated myocyte TNF-a production after the A/R was challenged ; surprisingly, HMGB1 itself did not induce myocyte TNF-a production