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EPHA3 — TNF

Text-mined interactions from Literome

Pan et al., Mol Cell Biol 2002 (Neovascularization, Pathologic) : We show that TNF activates Etk specifically through TNF receptor type 2 (TNFR2) as demonstrated by studies using a specific agonist to TNFR2 and TNFR2-deficient cells ... Thus, TRAF2 is not involved in TNF induced Etk activation, suggesting a novel mechanism for Etk activation by cytokine receptors
Zhang et al., J Biol Chem 2003 : Because TNF receptor 2 lacks an intrinsic kinase activity, we examined the kinase ( s ) mediating TNF induced Etk activation ... TNF induces a coordinated phosphorylation of vascular endothelial growth factor ( VEGF ) receptor 2 ( VEGFR2 ) and Etk , which is blocked by VEGFR2-specific inhibitors ... In response to TNF , Etk and VEGFR2 form a complex resulting in a reciprocal activation between the two kinases
Paulino et al., Planta Med 2006 (Inflammation...) : IN VITRO, G1 decreased nitric oxide production in LPS stimulated RAW 264.7 cells ( IC ( 50 ) = 41.60 microg/mL ), and also the luciferase activity in TNF-alpha stimulated HEK 293 cells transfected with NF-kappaB-luciferase reporter gene driven by the nuclear factor kappaB (NF-kappaB) ( IC ( 50 ) = 200 microg/mL )
Wang et al., Evidence-based complementary and alternative medicine : eCAM 2013 : In addition, using a reporter assay, we found that EECP could block the activation of NF-?B in TNF-a stimulated HEK 293T cells