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CD14 — TNF

Text-mined interactions from Literome

van Furth et al., Infect Immun 1999 : The objective of the present study was to investigate whether the production of tumor necrosis factor alpha (TNF) and interleukin-10 (IL-10) by human monocytes stimulated by intact heat killed or live Haemophilus influenzae or Streptococcus pneumoniae is mediated by CD14
Scragg et al., Eur J Immunol 1999 : Both CD3 ( + ) and CD14 ( + ) populations are required for this early TNF response to Pfe, whereas the endotoxin induced response is unaffected by depletion of the CD3 ( + ) population
Cuzzola et al., Infect Immun 2000 : Results indicate that CD14 plays an important role in tumor necrosis factor alpha responses to all of the stimuli tested
Flo et al., J Immunol 2000 : In contrast to this, anti-CD14 blocked LPS induced TNF production from monocytes, whereas anti-TLR2 showed no inhibition
Iwagaki et al., Infect Immun 2000 : The purpose of this study was to compare and contrast the endotoxin neutralizing activities of two synthetic antiendotoxin peptides ( SAEP-2 and SAEP-4 ), PMB, and an LPS core-specific monoclonal antibody ( MAb ), WN1 222-5, based on their abilities to inhibit CD14 mediated target cell uptake of fluorescein isothiocyanate ( FITC ) -conjugated LPS, detected by flow cytometry and confocal microscopy, and LPS induced production of the proinflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) , as measured by bioassays
Taylor et al., J Exp Med 2000 (Filariasis...) : We also show that CD14 is required for optimal TNF-alpha responses at low concentrations
Nadeau et al., J Neurosci 2000 (Endotoxemia) : Role of microglial derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia ... The present data provide the evidence that microglial derived TNF-alpha is responsible for the production of the LPS receptor CD14 during endotoxemia
Kragsbjerg et al., APMIS 2000 : The effects of human recombinant tumour necrosis factor-alpha (TNF-alpha) on neutrophil ( PMNL ) oxidative burst and on CD11b/CD18 and CD14 expression after stimulation with pathogenic or nonpathogenic Neisseria meningitidis were studied using chemiluminescence and flow cytometry ... Only TNF-alpha and the 29E strain caused significant increases in CD14 expression
Kawai et al., FEMS Immunol Med Microbiol 2000 : Ornithine containing lipids stimulate CD14 dependent TNF-alpha production from murine macrophage-like J774.1 and RAW 264.7 cells
Flo et al., Infect Immun 2000 : Treatment of monocytes with antibody to CD14, CD18, or CD11b showed that CD14 , but not CR3 ( CD11b/CD18 ), mediated monocyte TNF production in response to the soluble antigens
Nagaoka et al., J Immunol 2001 (Shock, Septic) : Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14 ( + ) cells
Brown et al., J Immunol 2001 : Treatment of cells with NaClO ( 3 ), an inhibitor of sulfation, prevented HA binding in a significant percentage of CD14 ( + ) PBMC induced by TNF-alpha , LPS, IL-1beta, or IFN-gamma
Li et al., Cell Growth Differ 2002 : Furthermore, up-regulation of TLR2 and CD14 mRNA expression by PMA was abrogated by a protein kinase C inhibitor, Calphostine C, suggesting the up-regulation of TLR2 and CD14 mRNA is dependent on the activation of protein kinase C. Coexpression of CD14/TLR2 and/or CD14/TLR4 may be essential but not sufficient for the production of tumor necrosis factor-alpha in response to lipopolysaccharide in our system
Fang et al., Zhonghua Wai Ke Za Zhi 1999 (Burns) : Excessive CD14 mRNA expression may enhance synthesis and release of TNF-alpha stimulated by endotoxin translocation, and the interaction between CD14 and TNF-alpha may play an important role in mediating multiple organ damage secondary to major burns
Heesen et al., Eur Cytokine Netw 2002 : No association was found between the CD14 -260 genotypes or the TNF-alpha -308 - CD14 -260 genotypes and the TNF-alpha response
Ishii et al., Nihon Kyobu Shikkan Gakkai Zasshi 1992 (Acute Disease...) : Airspace accumulation of LBP secondary to increased vascular and epithelial permeability may play a critical role in the development of septic shock and lung injury by promoting TNF alpha production via a CD14 dependent mechanism
Witcher et al., Blood 2004 (Leukemia, Promyelocytic, Acute) : Using neutralizing antibodies against m-CSF-1R or its ligand, we found that inhibiting this pathway strongly reduced CD14 expression in response to RA and TNF , suggesting that this pathway is essential for their synergy in RA-resistant leukemia cells
Peng et al., Zhonghua Gan Zang Bing Za Zhi 2005 (Reperfusion Injury) : Glycine could efficiently protect rat liver grafts from ischemia-reperfusion injury by repressing the expression of CD14 and NF-kappa B binding activity in Kupffer cells and inhibiting the productions of TNF alpha and IL-1
Ji et al., Zhong Xi Yi Jie He Xue Bao 2006 : QGHXR could down regulate the expressions of membrane receptors CD14 and TLR(4) and inhibit the expressions of NF-kappaB and TNF-alpha ... QGHXR can protect liver cells by down regulating the expressions of CD14 , TLR(4) and NF-kappaB and inhibiting TNF-alpha expression
Albers et al., Microbiology 2007 : The two L. pneumophila lpxB paralogues are not functionally equivalent, since expression of lcsC/lpxB1 but not lpxB2 in an L. pneumophila icmG mutant is cytotoxic for A. castellanii, and LPS purified from the two strains triggers CD14 dependent tumour necrosis factor (TNF)alpha production by macrophages with a different potency
Chaudhuri et al., Placenta 2009 (Cytomegalovirus Infections) : The interaction of UV-HCMV and HCMV with CD14 on the surface of ST-like cells increases TNFalpha expression and induces apoptosis in the population
Anas et al., PloS one 2010 (Acute Disease...) : Strikingly, neutrophil influx and TNF release induced by high dose S-LPS or R-LPS was diminished in the presence of CD14
Chávez-Sánchez et al., Hum Immunol 2010 : Our results suggest that mmLDL activates CD14 , TLR4, and TLR2, inducing the production of TNF-alpha and increasing the expression of TLR2 and TLR4
Pedraza-Sánchez et al., Clinical and vaccine immunology : CVI 2013 : Thus, a reduced CD14 ( + ) CD16 ( + ) activated/differentiated monocyte subset and a correspondingly lower level of functional TLR4 on monocytes contributes to the relatively low TNF-a response to LPS observed in immunologically naive newborns compared to the response in adults
Czerkies et al., Immunobiology 2013 : These data indicate that SR-A is required for maximal production of TNF-a in cells stimulated with LPS, possibly by modulating the cell surface levels of TLR4 and CD14
Treon et al., Leuk Res 1994 (Leukemia, Myeloid, Acute...) : CD14 mediated endogenous TNF-alpha release in HL60 AML cells : a potential model for CD14 mediated endogenous cytokine release in the treatment of AML ... CD14 mediates TNF release in monocytes/macrophages in response to binding of LPS with LPS binding protein (LBP)
Haziot et al., J Immunol 1994 (Shock, Septic) : Recombinant soluble CD14 inhibits LPS induced tumor necrosis factor-alpha production by cells in whole blood
Dimri et al., Lymphokine Cytokine Res 1994 : Adherent human peripheral blood monocytes cultured for 2 weeks in the presence of GM-CSF or IL-3 were examined for viability and adherence, expression of membranal HLA-DR, CD-14 , and IL-1 alpha, and LPS triggered TNF-alpha production
Parker et al., Infect Immun 1995 : Anti-CD14 monoclonal antibodies MY4 and 3C10 inhibited LPS binding protein and CD14 dependent activation of TNF-alpha production by LPS at LPS concentrations up to approximately 1.0 ng/ml. R-HDL ( 2 mg of protein per ml ) blocked TNF-alpha production by LPS from both smooth- and rough-type gram negative bacteria at concentrations up to 100 ng of LPS per ml but had little effect on heat killed gram positive Staphylococcus aureus and no effect on other LPS independent stimuli tested
Soell et al., J Immunol 1995 : Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by CD14 antigen , and mannan binding protein inhibits TNF-alpha release
Takasuka et al., J Immunol 1995 : Our results also suggest that, in P-PEM, in contrast to J774.1 cells and T-PEM, neither PKC nor CD14 is involved in the LPS induced activation and suppression of TNF-alpha gene expression
Sundan et al., Scand J Immunol 1995 (Hemoglobinuria, Paroxysmal) : The involvement of CD14 in stimulation of TNF production from peripheral mononuclear cells isolated from PNH patients
Jahr et al., Scand J Immunol 1995 : In this study we examined the involvement of human serum, recombinant lipopolysaccharide binding protein ( rLBP ), recombinant ( r ) CD14 , CD14 antibodies and recombinant bactericidal permeability increasing factor ( rBPI ) in the induction of TNF by Salmonella minnesota LPS of different polysaccharide chain lengths
Cosentino et al., J Immunol 1995 : Indeed, CD14 mediated release of TNF-alpha was inhibited markedly ( approximately 75 % ) in monocytes stimulated with LPS ( 100 ng/ml ) after a 72-h preincubation with IL-13
Dentener et al., J Immunol 1993 : Involvement of CD14 in lipopolysaccharide induced tumor necrosis factor-alpha , IL-6 and IL-8 release by human monocytes and alveolar macrophages ... We conclude that CD14 is involved in LPS induced release of TNF-alpha , IL-6, and IL-8 by monocytes and alveolar macrophages and that this receptor appears to be able to recognize LPS directly in the absence of serum
Weber et al., Eur J Immunol 1993 : Moreover, TNF induced a moderate increase of CD14 surface antigen expression, used as a phenotypic marker of monocyte/macrophage differentiation
Weingarten et al., J Leukoc Biol 1993 : The increases in CR3 and CD14 occurred in parallel and were independent of protein synthesis and tumor necrosis factor (TNF) production
Nwariaku et al., J Trauma 1996 (Shock, Hemorrhagic) : The CD14 inhibition resulted in a 55 % reduction in baseline TNF activity ... The enhanced whole blood monocyte TNF response after hemorrhage is CD14 dependent
Cunningham et al., Infect Immun 1996 : With Escherichia coli LPS, tumor necrosis factor alpha activation requires membrane bound CD14 and E-selectin expression requires soluble CD14 ( sCD14 )
Takakuwa et al., Eur J Immunol 1996 : Furthermore, exogenous recombinant tumor necrosis factor (TNF) induced in vivo and in vitro enhanced CD14 expression in Lpsn, Lpsd and also in TNF receptor 2-deficient (TNFR2-/-) mice, but failed to do so in TNFR1-/- mice, showing that TNFR1 mediates the effect of TNF on CD14
Jahr et al., Infect Immun 1997 : In this study we have investigated the effects of soluble CD14 ( sCD14 ), lipopolysaccharide binding protein (LBP), and bactericidal/permeability increasing factor ( BPI ) on poly ( M ) binding to monocytes and induction of TNF production
Chaka et al., Infect Immun 1997 : The results indicate that ( i ) induction of TNF-alpha by C. neoformans and GXMs strongly depends on complement, ( ii ) MP1 and MP2 induction of TNF-alpha is facilitated by a heat-stable serum factor other than Ig, and ( iii ) CD14 may be involved in the induction of TNF-alpha by MP2
Jersmann et al., Infect Immun 1998 : The results demonstrate that TNF significantly increases the LPS induced release of oxygen radicals in neutrophils through the upregulation of cell surface CD14
Medvedev et al., J Immunol 1998 : Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls ... This study was undertaken to evaluate the role of CD14 and complement receptors type 3 ( CR3 ) and 4 ( CR4 ) in mediating TNF release and NF-kappaB activation induced by LPS and cell wall preparations from group B streptococci type III ( GBS ) ... LPS and GBS caused TNF secretion from human monocytes in a CD14 dependent manner, and soluble CD14 , LPS binding protein, or their combination potentiated both LPS- and GBS induced activities
Heinzelmann et al., J Immunol 1998 : These data suggest that mechanisms other than increased CD14 expression are responsible for the enhanced release of TNF-alpha or PGE2 in response to HBP and LPS
Lichtman et al., Am J Physiol 1998 : CD14 expression is very low in Kupffer cells, and LPS stimulated TNF-alpha release is independent of CD14 in these cells
Lien et al., Blood 1998 (Disease Progression...) : Furthermore, MAC-PPD induced tumor necrosis factor (TNF) release from monocytes through interactions with CD14 and, importantly, the addition of sCD14 enhanced this MAC-PPD stimulatory effect
Netea et al., Immunology 1998 : TNF-alpha production is essentially CD14 dependent , both in the presence or absence of plasma
Comstock et al., J Mol Cell Cardiol 1998 (Necrosis) : LPS induced TNF-alpha release from and apoptosis in rat cardiomyocytes : obligatory role for CD14 in mediating the LPS response