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BMP4 — TNF

Text-mined interactions from Literome

Horiguchi et al., Cytokine 2000 : These results indicate that TNF-alpha stimulates both cell proliferation and BMP-4 expression but inhibits chondrogenesis in chondroprogenitor-like ATDC5 cells
Kaneki et al., J Biol Chem 2006 : TNF inhibited the expression of bone morphogenetic protein and transforming growth factor-beta signaling reporter constructs, and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA, respectively
He et al., Zhonghua Wai Ke Za Zhi 2006 : To study the feasibility of osteogenic phenotype expression by human skin fibroblasts induced in polyglycolic acid ( PGA ) foams and the effect of tumor necrosis factor-alpha (TNF-alpha) on the expression of bone morphogenetic protein ( BMP ) receptors
Singhatanadgit et al., Int J Biochem Cell Biol 2006 : Bone morphogenetic protein receptors and bone morphogenetic protein signaling are controlled by tumor necrosis factor-alpha in human bone cells
Zhu et al., Gene 2007 : TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells ... In this study we examined whether TNF-alpha , which activates NF-kB, can regulate Bmp4 gene expression ... TNF-alpha reduced Bmp4 mRNA in lung adenocarcinoma A549 cells and repressed transcriptional activity of the human Bmp4 promoter in a dose dependent manner ... In support of this finding, the repressor effect of TNF-alpha on Bmp4 was abrogated by a co-transfected dominant negative mutant of IkB ( S32A/S36A )
Hong et al., Immunology 2009 : In addition, BMP-6 induced expression of pro-inflammatory inducible nitric oxide synthase (iNOS) and the cytokine tumour necrosis factor (TNF)-alpha
Yamazaki et al., J Biol Chem 2009 : These results suggest that TNFalpha inhibits BMP signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB
Xu et al., FASEB J 2011 (Choroidal Neovascularization...) : Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age related macular degeneration
Pacios et al., FASEB J 2012 (Diabetes Mellitus, Experimental...) : TNF inhibition in diabetic animals also reduced apoptosis, increased proliferation of bone lining cells, and increased mRNA levels of FGF-2, TGFß-1, BMP-2 , and BMP-6
Nakase et al., Bone 1997 : The modulatory effects of interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha on bone morphogenetic protein (BMP)-2- and -4-induced alkaline phosphatase (ALP) activity were examined in cultures of mouse MC3T3-E1 osteoblastic cells