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NOS2 — TLR9

Text-mined interactions from Literome

Brightbill et al., Science 1999 : Several lipoproteins stimulated TLR dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway
Suliman et al., FASEB J 2005 : In wild-type ( Wt ) mice injected with heat inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with TLR dependent increases in transcript levels for tumor necrosis factor ( TNF-alpha ), interleukin 6, nitric oxide synthase-II ( iNOS ), and NADPH oxidase 2 (Nox2)
Copin et al., J Immunol 2007 (Brucellosis) : Using genetically deficient mice, we demonstrated that the induction of iNOS and IFN-gamma producing cells due to Brucella infection required TLR4 and TLR9 stimulation coupled to Myd88 dependent signaling pathways
Liese et al., Eur J Immunol 2007 (Leishmaniasis, Cutaneous) : Although TLR9 deficiency led to a transient increase of IL-4, IL-13 and arginase 1 mRNA and a reduced expression of iNOS at the site of infection and in the draining lymph nodes, it did not prevent the development of Th1 cells and the ultimate resolution of the infection
Tsukamoto et al., J Immunol 2008 : Previous pharmacologic studies have suggested that a PI3K-Akt pathway negatively regulates TLR induced inducible NO synthase expression and cytokine production
Lee et al., Biochem Biophys Res Commun 2007 : Toll-like receptor 9-mediated cytosolic phospholipase A2 activation regulates expression of inducible nitric oxide synthase ... Here, we show that cytosolic phospholipase A ( 2 ) ( cPLA(2) ) activation is important for TLR9 mediated inducible nitric oxide synthase (iNOS) expression ... Activation of TLR9 signaling by CpG induces iNOS expression and NO production ... Inhibition of TLR9 blocked the iNOS expression and NO production ... These results suggest that TLR9 activation stimulates cPLA(2) activity via p38 or Akt pathways and mediates iNOS expression
Masamune et al., J Gastroenterol 2008 : TLR ligands induced expression of monocyte chemoattractant protein 1, cytokine induced neutrophil chemoattractant 1 ( a rat homolog of interleukin-8 ), and inducible nitric oxide synthase , but not proliferation or type I collagen production
Lin et al., Mol Immunol 2010 : Nevertheless TLR mediated JNK activation as well as the increased protein expression of iNOS and COX-2 remained unchanged when Syk protein was knockdown by siRNA approach