Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
NRF1
→
PPARGC1A
(increases, PPARGC1A Activity, NRF1 Activity)
Ojuka et al., Proc Nutr Soc 2004* Evidence: PGC-1, NRF-1, NRF-2 and PPARa are involved in the stimulation of mitochondrial biogenesis by exercise and that activation of NRF-1, NRF-2 and PPARa by PGC-1 results in a well-coordinated expression of mitochondrial proteins.
OpenBEL Selventa BEL large corpus:
NRF1
→
PPARGC1A
(increases, PPARGC1A Activity, NRF1 Activity)
Ojuka et al., Proc Nutr Soc 2004* Evidence: Activation of NRF-1 by PGC-1 increases the expression of genes that encode mitochondrial respiratory chain proteins (Scarpulla, 2002) and 5-aminolevulinate synthase (Briadotti et al. 1993), as well as mitochondrial transcription factor A, a regulator of mitochondrial DNA transcription and replication