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NOX1 — VAV2

Text-mined interactions from Literome

Yi et al., Cell Physiol Biochem 2007 : Mechanism of homocysteine induced Rac1/NADPH oxidase activation in mesangial cells : role of guanine nucleotide exchange factor Vav2 ... These results suggest that Vav2 importantly contributes to Hcys induced increase in Rac1 activity and consequent activation of NADPH oxidase in RMCs via ceramide associated tyrosine phosphorylation
Yi et al., Hypertension 2009 (Disease Models, Animal...) : We concluded that Vav2 mediated activation of NADPH oxidase is an important initiating mechanism resulting in hyperhomocysteinemic glomerular injury through enhanced local oxidative stress
Xu et al., PloS one 2013 : Correspondingly, NOX1 gene silencing abolished ET-1 induced O2 ( ·- ) production and increased CD38-ADP-ribosylcyclase activity in CAMs, while activation of NOX1 by overexpression of Rac1 or Vav2 or administration of exogenous O2 ( ·- ) significantly increased CD38 internalization in CAMs