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IL12B — MAPK13

Pathways - manually collected, often from reviews:

• KEGG Tuberculosis: MAPK11/MAPK12/MAPK13/MAPK14 → IL12A/IL12B (gene expression, expression)

Text-mined interactions from Literome

Kang et al., Biochem Pharmacol 2002 : Berberine induced IL-12 p40 production and activation of p38 mitogen activated protein kinase ( MAPK ) in dose dependent manners, which were significantly inhibited by p38 MAPK inhibitors and yohimbine, indicating that p38 MAPK and alpha ( 2 ) -adrenergic receptor were involved in the induction of IL-12 p40 production in mouse macrophages by berberine
Feng et al., Cell Res 2002 (Inflammation) : cAMP elevators inhibit LPS induced IL-12 p40 expression by interfering with phosphorylation of p38 MAPK in murine peritoneal macrophages
Kang et al., Eur J Pharmacol 2003 : Inhibitors of p38 MAPK prevented the stimulatory effects of alpha ( 2 ) -adrenoceptor agonists on IL-12 production
Utsugi et al., J Immunol 2003 (MAP Kinase Signaling System) : c-Jun N-terminal kinase negatively regulates lipopolysaccharide induced IL-12 production in human macrophages : role of mitogen activated protein kinase in glutathione redox regulation of IL-12 production
Kikuchi et al., Immunol Lett 2003 : It seems that roles of ERK and p38 MAPK for IL-12 production are developmentally changed in murine DC
Ma et al., J Immunol 2004 : Taken together, our results suggest that DXM may inhibit IL-12p40 production in LPS stimulated human monocytic cells by down regulating the activation of JNK MAPK , the AP-1, and NF-kappaB transcription factors ... A role for c-Jun N-terminal kinase (JNK) MAPK in LPS induced IL-12p40 regulation in a promonocytic THP-1/CD14 cell line was demonstrated by using specific inhibitors of JNK activation, SP600125 and a dominant negative stress activated protein/extracellular signal regulated kinase kinase-1 mutant
Yu et al., J Immunol 2004 : CD40L induced monocyte derived DC IL-12 production was mediated by both the p38 MAPK and PI3K pathways
Ichikawa et al., Biol Pharm Bull 2004 : These results suggest that gallate containing catechins, particularly EGCG, inhibits LPS induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation
Mason et al., Infect Immun 2004 : The studies presented here demonstrate for the first time that the production of IL-12 ( p40 ) in response to toxoplasma is dependent upon TRAF6 and p38 MAPK
Kim et al., J Immunol 2005 (Infection...) : Chemical inhibition of stress activated protein kinase/JNK showed that this MAPK was also required for parasite triggered IL-12 production
Yanagawa et al., Immunology 2006 : Taken together, we concluded that IL-6 and IL-12 productions in response to CD40 ligation were controlled by p38 MAPK and NIK mediated alternative pathway, respectively, in mature DCs
Kitanaka et al., Biochem Biophys Res Commun 2006 : Collectively, it is suggested that E-FABP may be a novel negative regulator of IL-12 production in DCs, and this regulation may be exerted via its involvement in the p38MAPK mediated transcription of IL-12p35
He et al., J Immunol 2006 : Expression of IL-12p40 required activation of the p38 MAPK and PI3K
Koch et al., Respir Med 2007 (Asthma) : The modulatory role of extracellular signal regulated kinase ( ERK ) -1/-2, p38mitogen activated protein kinase ( MAPK ) and dexamethasone on IL-12 induced T-bet and IFNgamma expression was assessed in peripheral blood lymphocytes of 10 atopic asthmatics and 10 nonatopic normals
Usluoglu et al., Eur J Immunol 2007 : Different signal pathways mediate LPS induced expression of IL-12 and involve PI3K, MAPK and the transcription factor NF-kappaB
Cheung et al., J Immunol 2008 (Inflammation) : Further investigations showed that IL-17A, IL-17F, and IL-23 differentially activated the ERK, p38 MAPK , and NF-kappaB pathways
Brereton et al., J Immunol 2009 (Autoimmune Diseases) : Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease ... In this study, we show that inhibition of ERK MAPK suppressed IL-23 and IL-1beta production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production ... In this study, we show that inhibition of ERK MAPK suppressed IL-23 and IL-1beta production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production
Boucher et al., Viral Immunol 2010 (HIV Infections...) : The role of MAPK signaling in transcription factor binding to the IL-12p40 promoter was subsequently determined
Mitchell et al., J Infect Dis 2010 : IL-12p40 was significantly inhibited by both p38 mitogen activated protein kinase ( MAPK ) and extracellular signal regulated kinase inhibitors, whereas IL-12p70 was inhibited by p38 MAPK inhibitor alone
Antonios et al., J Immunol 2010 (MAP Kinase Signaling System) : Our results showed that p38 MAPK , NF-kappaB, and IRF-1 were involved in IL-12p40 production induced by NiSO ( 4 )
Dong et al., Phytomedicine 2011 : Furthermore, specific pharmacological inhibitors of ERK kinase ( U0126 ) and p38 MAPK ( SB203580 ) also suppressed the production of IL-12 induced by garlic lectin
Bebien et al., PLoS Pathog 2012 (Streptococcal Infections) : ßh/c mediated activation of p38 MAPK drives expression of the anti-inflammatory and immunosuppressive cytokine IL-10, and inhibits both IL-12 and NOS2 expression in GBS infected macrophages, which are critical factors in host defense
McBerry et al., J Immunol 2012 (Disease Models, Animal...) : p38 MAPK activation and IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2 suppressed TLR induced IL-12/23p40 production ... p38 MAPK activation and IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2 suppressed TLR induced IL-12/23p40 production