Abe et al., J Biol Chem 2000
:
The MEK-1 inhibitor, PD98059 ( 30 microM ), inhibited H ( 2 ) O ( 2 ) -mediated activation of ERK1/2 but not of p90RSK Manhas et al., J Neurochem 2010
(Brain Ischemia...) :
Stimulation of p90 ( RSK ) in ischemic neurons was downstream of ERK activation because inhibition of MEK1 ( MAP kinase/ERK kinase ) with its inhibitor U0126 blocked phosphorylation of p90 ( RSK )