Ludwig et al., Cancer Res 2001
(Carcinoma, Medullary...) :
RET induced NF-kappaB and IKKbeta activity requires Ras function but does neither involve the classical mitogen activated protein kinase kinase/extracellular signal regulated kinase nor the phosphoinositide 3-kinase/Akt pathways
Chen et al., J Biol Chem 2007
:
In conclusion, MEK1 , TAK1, NF-kappa inducing kinase, and PI3K are required for iron induced IKK activation in hepatic macrophages and TAK1, PI3K, and p21ras physically interact in caveolae to initiate signal transduction