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IFNG — PRM2
Text-mined interactions from Literome
Li et al., Am J Physiol 1999
(Lung Diseases) :
In an effort to elucidate the mechanism of gene inactivation, we report in this study that cationic
lipid-protamine-DNA ( LPD ) complexes, but not each component alone, can
induce a high level of cytokine production, including
interferon-gamma and tumor necrosis factor-alpha
Däubener et al., J Interferon Cytokine Res 1996
(Glioblastoma) :
In this report, we show that the antagonistic effect of protamine on heparin mediated inhibition of
IFN-gamma activity is mainly
due to the capacity of
protamine to enhance IFN-gamma activity ... We found that
protamine enhances the capacity of
IFN-gamma to inhibit the growth of different brain tumor cell lines, to induce indolamine 2, 3-dioxygenase activity, to induce toxoplasmostasis, and to induce MHC class II antigen expression in human glioblastoma cells and in human native fibroblasts ... We were able to demonstrate that IFN-gamma binds to protamine, and, therefore, we assume that the
effect of
protamine on
IFN-gamma is due to a direct interaction between the two molecules