◀ Back to IFNG
IFNG — PRKAR1B
Text-mined interactions from Literome
Osna et al., Int Immunopharmacol 2001
:
PKA played a role in the inhibition of
IFN gamma by histamine when the cells were activated via TCR, and the PKA inhibitors Rp-cAMPS ( 10 ( -5 ) M ) and H8 ( 10 ( -5 ) M ) reversed the inhibitory effects of histamine on IFN gamma production ... However, when the cells were stimulated with ionomycin, the
PKA inhibitors did not
affect histamine mediated suppression of
IFN gamma production
Cochrane et al., J Interferon Cytokine Res 2001
:
In contrast, inhibitors of
PKA or NOS, but not catalase,
prevented FSK induced suppression of
IFN-gamma production
Williams et al., J Immunol 2002
:
Disruption of the
AKAP-PKA interaction
caused high levels of IL-2, IL-4, IL-5, and
IFN-gamma production in the absence of stimulation via CD3epsilon and CD28 molecules
Liu et al., J Interferon Cytokine Res 2004
:
Experimental data indicate that exogenous
IFN-gamma stimulated cAMP accumulation and
PKA activation in time dependent and dose dependent manners in murine peritoneal macrophages ... Moreover,
IFN-gamma stimulated CREB phosphorylation and CREB DNA binding, which could be significantly attenuated by
PKA inhibition with H89
Hughes-Fulford et al., Cell Signal 2005
:
Gene expression of IL-2R ( alpha ) and
IFN(gamma) was
dependent on
PKA in S49 wt cells but not in kin- mutants ... Taken together, these results suggest that the
PKA in addition to PKC and MAPK pathways
plays a role in early T-cell activation and induction of IL-2, IL-2R ( alpha ) and
IFN(gamma) gene expression
Bakhiet et al., Eur J Immunol 1993
:
Although both the PKC and the
PKA inhibitors
suppressed PHA induced
IFN-gamma secretion and proliferation of rat MNC and mouse CD8+ CD4- MNC, they had no effect on the same TLTF induced responses