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IFNG — MMP14
Text-mined interactions from Literome
Nold et al., Naunyn Schmiedebergs Arch Pharmacol 2003
:
Whereas IL-18 and TNFalpha induced the protease,
MMP-9 release was not
mediated by
IFNgamma
Alvarado et al., Cytokine 2008
:
In this report, the
effects of the bacterial lipopolysaccharide (LPS) and ECM bound
IFN-gamma on
MT1-MMP expression and MMP-2 activity were evaluated by Western blot, RT-PCR and zymography in isolated intestinal epithelial and cultured HT-29 cells ... In the presence of LPS, ECM bound
IFN-gamma , but not soluble IFN-gamma,
reduced the enterocyte
MT1-MMP protein expression
Wang et al., World J Gastroenterol 2008
(Liver Cirrhosis) :
Both Cpd 861 and
IFN-gamma reduced the mRNA levels of collagen type III,
MMP-2 and TGF-beta1
Nareika et al., Atherosclerosis 2009
(Atherosclerosis...) :
Results showed that high glucose and
IFN gamma had a synergistic effect on the expression of MMP-1,
MMP-9 and IL-1 beta
Mann et al., Ann Otol Rhinol Laryngol 1995
(Carcinoma, Squamous Cell...) :
Supernatants of HNSCC cell lines SCC-25 and FADU stimulated with interleukin (IL)-1 alpha and IL-1 beta demonstrated modest induction of 92 kd GL production by zymogram analysis when compared with controls ; IL-2, IL-6, and
interferon-gamma had no consistent effect on
MMP production
Varga et al., Adv Exp Med Biol 1996
:
Supplementation with tryptophan completely overcame the inhibitory
effects of
interferon-gamma on
MMP mRNA expression and metalloproteinase secretion into the media ... These results indicate that oxidative tryptophan metabolism mediates the
effects of
interferon-gamma on
MMP gene expression in human fibroblasts