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IFNB1 — IFNG
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IFNB1
(increases)
Evidence: IFNbeta altered the IFNgamma cytokine profile in unfractionated Peripheral blood mononuclear cells (PBMCs) primed in vitro with Myelin basic protein, The production of IFNgamma was augmented in culture (59pg/ml versus 105pgml).
Text-mined interactions from Literome
Cousens et al., J Exp Med 1999
(Lymphocytic Choriomeningitis) :
Under normal conditions of infections, the CD8 T cell
IFN-gamma response was
dependent on endogenous
IFN-alpha/beta effects, but was IL-12 independent
Bakhiet et al., Clin Diagn Lab Immunol 1999
(Multiple Sclerosis) :
The present work confirms in vivo the in vitro suppressive
effects of
IFN-beta-1b on
IFN-gamma production in MS
Cremer et al., J Immunol 2000
:
The constitutive
IFN-beta production also
resulted in an increased production of IL-12 and
IFN-gamma Th1-type cytokines and of the beta-chemokines macrophage-inflammatory protein-1alpha, macrophage-inflammatory protein-1beta, and RANTES
Khademi et al., J Neuroimmunol 2000
(Multiple Sclerosis, Relapsing-Remitting) :
These effects were not apparent after 2 weeks of treatment, and
IFNbeta-1a induced
IFNgamma production by naive PBMC in vitro
Nguyen et al., Nat Immunol 2000
(Virus Diseases) :
They also show that type 1 interferon signaling can occur through STAT1 dependent and independent mechanisms and suggest that efficient
induction of
IFN-gamma expression by
IFN-alpha/beta requires STAT1 regulation
Krug et al., Eur J Immunol 2001
:
IFNgamma production in PBMC was
dependent on CpG ODN induced
IFN-alpha/beta as demonstrated by IFN-alpha/beta blocking antibodies
Mitani et al., Genes Cells 2001
:
Previously, we reported on the critical
role of the
IFN-alpha/beta signalling complex, generated by spontaneously produced IFN-alpha/beta, in efficient
IFN-gamma signalling
Iarlori et al., J Neuroimmunol 2002
(Multiple Sclerosis...) :
IFNbeta-1b , in vitro,
increases MCP-1, TNFalpha and
IFNgamma spontaneous production in all patients
Costa-Pereira et al., J Virol 2002
:
Accordingly, possible roles for autocrine or double-stranded-RNA ( dsRNA ) -induced
IFN-alpha/beta in the
IFN-gamma response were investigated ...
IFN-gamma did not
induce detectable levels of
IFN-alpha/beta in any of the cell lines, nor was the IFN-gamma response per se dependent on autocrine IFN-alpha/beta
Soos et al., J Immunol 2002
(Encephalomyelitis, Autoimmune, Experimental) :
Whereas
IFN-alpha and -beta induced
IFN-gamma secretion, a Th1 cytokine, IFN-tau did not
Nguyen et al., Science 2002
(Arenaviridae Infections) :
Here we show that
IFN-alpha/beta activate STAT4 directly ( STAT, signal transducers and activators of transcription ) and that this is
required for
IFN-gamma production during viral infections of mice, in concert with T cell receptor derived signals ... In contrast, STAT1 appears to negatively regulate
IFN-alpha/beta induction of
IFN-gamma
Hua et al., J Neurochem 2002
:
Electrophoretic mobility shift analysis ( EMSA ) demonstrated that
IFN-gamma induced sustained IFN-gamma activated sequence ( GAS ) binding, while
IFN-beta induced transient GAS binding
Malmgaard et al., J Gen Virol 2003
(Herpes Simplex) :
Interferon (IFN)-alpha/beta , interleukin (IL)-12 and IL-18 coordinately
induce production of
IFN-gamma during infection with herpes simplex virus type 2
Gobl et al., Scand J Immunol 1992
:
IFN-gamma had only a minor reversing effect on the rIL-4 inhibition, but if cells were precultivated in medium with or without IFN-gamma for 6 h before SV induction, rIL-4 paradoxically
enhanced the
IFN-alpha/beta response
Une et al., Clin Exp Immunol 2003
(Chagas Disease) :
Role of
IFN-alpha/beta and IL-12 in the activation of natural killer cells and
interferon-gamma production during experimental infection with Trypanosoma cruzi
Peters et al., Immunology 2003
:
Mitogen stimulation of embryonic day 18 and day 1 post-hatch thymocytes
induced up-regulation of IFN-gamma, IL-1beta and TGF-beta transcripts, and down-regulation of IFN-alpha,
IFN-beta and IL-2 transcripts, with a higher induction of
IFN-gamma , IL-1beta and TGF-beta transcripts in more immature T-cell-receptor negative ( TCR- ) than TCR+ ( TCR1+, TCR2+, or TCR3+ ) subsets
Strengell et al., J Leukoc Biol 2004
:
In addition,
IFN-alpha/beta enhanced T cell receptor stimulation induced IL-21 and
IFN-gamma gene expression in resting T cells
Mattner et al., J Immunol 2004
(Disease Progression...) :
IFN-beta treatment of BALB/c mice restored the NK cell cytotoxic activity, increased the lymphocyte proliferation, and
augmented the production of
IFN-gamma and IL-12 in the draining lymph node ... The
IFN-beta induced increase of
IFN-gamma production was dependent on STAT4
Marziali et al., J Virol 1991
(Leukemia, Erythroblastic, Acute) :
Treatment of Friend erythroleukemia cells ( FLC ) with gamma interferon ( IFN-gamma ) in the presence of anti-IFN-beta antibodies reduces the effectiveness of the antiviral state and the induction of 2'-5'-oligoadenylate synthetase activity, indicating that the antiviral activity of
IFN-gamma in FLC is in part
mediated by the production of
IFN-beta ... These results indicate that posttranscriptional mechanisms are involved in the
regulation of
IFN-beta and -alpha expression by
IFN-gamma
Nozell et al., J Immunol 2006
(Astrocytoma) :
IFN-gamma-inducible protein-10 and MCP-1 genes, also regulated by NF-kappaB, are unaffected by
IFN-beta , and IFN-beta does not
prevent the activation, nuclear migration, or binding of NF-kappaB p65 to the kappaB element of the
IFN-gamma-inducible protein-10 promoter
Fahey et al., J Leukoc Biol 2007
:
However, despite this up-regulation,
IFN-beta suppressed IL-12 induced
IFN-gamma expression
Hamamcioglu et al., Mult Scler 2007
(Disease Progression...) :
IFN-beta in vitro strongly
induced IL-10 and
IFN-gamma in activated T cells in RRMS, but not in progressive MS, suggesting IFN resistance
Arakura et al., J Immunol 2007
(Disease Models, Animal...) :
Notably,
IFN-gamma expression as well as spontaneous
IFN-alpha/IFN-beta responses were up-regulated several fold spontaneously in the skin in IRF-2 ( -/- ) BN mice but not in IRF-2 ( -/- ) mice with `` resistant '' backgrounds
Le-Thi-Phuong et al., Int Immunol 2007
(Arterivirus Infections...) :
In sharp contrast with other viral infections,
IFN-alpha/beta diminished
IFN-gamma production and the resulting increased response to LPS in LDV infected animals
Feduchi et al., Virology 1991
:
Antibodies against IFN beta block this synergism, implying a
role of
IFN beta in the antiviral activity of TNF plus
IFN gamma
Hedegaard et al., Clin Immunol 2008
(Multiple Sclerosis) :
Thus,
IFN-beta inhibits
IFN-gamma production in general, presumably alleviating the detrimental influence of IFN-gamma in MS
Shirahata et al., Nihon juigaku zasshi. The Japanese journal of veterinary science 1990
(Disease Susceptibility...) :
Cs-A did not suppress the production of
intereferon(IFN)-alpha/beta that was
induced shortly after the infection, whereas it reduced greatly the ability of Toxoplasma infected mice to produce
IFN-gamma induced by stimulation with Toxoplasma lysate antigen ( TLA )
Blanchard et al., Infect Immun 1985
:
In whole-spleen cultures that were allowed to age for 24 to 48 h before stimulation, F-1 was seen to
induce mostly
IFN-gamma , with low levels of
IFN-alpha/beta present
Nickoloff et al., J Invest Dermatol 1987
:
The binding of human
IFN-gamma , to keratinocytes was
inhibited by human r-IFN-gamma, but not by either murine recombinant gamma interferon or human recombinant beta interferon (
r-IFN-beta )
Gessani et al., J Virol 1989
:
Secretion of
IFN-beta is also
induced in PM by
IFN-gamma ... These cells are
induced to secrete
IFN-beta by LPS but not by
IFN-gamma , suggesting that this cytokine may elicit such specific response only in PM. IFN-beta mRNA is undetectable in untreated RAW 264.7 cells, and accumulation of this mRNA is induced by LPS but not by IFN-gamma ... The
induction of
IFN-beta by
IFN-gamma appears to be a characteristic response of PM and may be at least in part responsible for the resistance of these cells to viral infections
Nakane et al., Infect Immun 1988
(Listeriosis) :
The effect of endogenous TNF on antilisterial resistance was due to neither regulation of alpha interferon ( IFN-alpha ) and
IFN-gamma production nor
induction of
IFN-beta subtype 1 (IFN-beta 1) , because anti-TNF antibody treated-mice produced normal levels of IFN-alpha and IFN-gamma in the bloodstream during infection and administration of monoclonal anti-murine IFN-beta 1 antibody had no effect on the development of listeriosis
Watanabe et al., Immunology 1988
:
The results show that
IFN-beta strongly
suppressed the induction of
IFN-gamma mRNA transcription and, interestingly, profoundly decreased the steady-state level of the T-cell receptor beta-chain ( TCR beta ) gene mRNA without any substantial effect on some other gene expressions, such as those of the interleukin-2 (IL-2) and the major histocompatibility complex ( MHC ) class I genes
Capobianchi et al., Hum Immunol 1985
(Melanoma) :
The results can be summarized as follows : class II molecules are markedly
increased by
IFN gamma ;
IFN beta has a lower enhancing effect, and IFN alpha has only a slight, if any, effect
Fleischmann et al., J Interferon Res 1984
(Melanoma) :
Further, the antiviral and anticellular activities of IFN-alpha and
IFN-beta were
potentiated equally by
IFN-gamma
Weinberg et al., Proc Natl Acad Sci U S A 1984
:
The effect was seen with both recombinant
IFN-gamma and natural IFN-gamma produced by Staphylococcal enterotoxin A-stimulated lymphocytes, but IFN-alpha ( leukocyte derived and recombinant ) and
IFN-beta did not
induce MP formation
Ma et al., Infect Immun 1994
:
As tumor necrosis factor alpha,
IFN-beta , and IL-12 are potent
activators of
IFN-gamma production by T and NK cells, their presence in these cocultures could be responsible for the IFN-gamma production
Kadereit et al., J Interferon Res 1994
:
For example, in HeLa cells, IFN-alpha or
IFN-beta induced similarly both PKR and p48 whereas
IFN-gamma induced mainly p48
Huang et al., Diabetes 1995
(Diabetes Mellitus, Type 1) :
In contrast,
IFN-beta was
detected at comparable levels in both groups, while
IFN-gamma was detected in three of four control pancreases and one of four pancreases from the diabetic individuals
Dalsgaard et al., Placenta 1995
(Pregnancy Complications, Neoplastic...) :
Tro-IFN-beta , -alpha and leu-IFN-alpha
induced high levels of 2-5A synthetase activity in placental fibroblast, BeWo and FEG-3 cell-lines, whereas
rec-IFN-gamma treatment did not induce 2-5A synthetase activity in any of these cells
Le et al., Int J Cancer 1995
(Adenocarcinoma...) :
Expression of sHLA is unlikely to result from IFN-gamma induced enhancement of overall HLA-class-I expression, as at low concentrations IFN-alpha,
IFN-beta and IFN-gamma
stimulated increased expression of cell membrane HLA-class-I molecules in Colo205 cells with almost equal efficiency, whereas only
IFN-gamma induced high level production of sHLA
Zhou et al., J Interferon Cytokine Res 1995
(Leukemia L1210) :
In the present study, the
effect of exogenous
IFN-gamma on the induction of endogenous mRNA synthesis and secretion of
IFN-alpha/beta by murine M phi was investigated ... These data indicate that exogenous
IFN-gamma induces endogenous synthesis and secretion of
IFN-alpha/beta by M phi, which appears to act in concert with endogenously synthesized TNF-alpha for the autocrine induction of NOS mRNA synthesis
Miller et al., J Neuroimmunol 1996
(Autoimmune Diseases...) :
Basal expression of ICAM-1 molecules was enhanced by TNF alpha and to a lesser extent by
IFN-beta , but was not
affected by
IFN-gamma
Kolosov et al., J Interferon Cytokine Res 1996
:
Previous studies suggested that
IFN-gamma induced endogenous synthesis of
IFN-alpha/beta by murine macrophages ... We tentatively conclude that
IFN-gamma stimulates macrophage synthesis and secretion of
IFN-alpha/beta , which in turn promotes C1q mRNA synthesis in an autocrine or paracrine manner
Cousens et al., Proc Natl Acad Sci U S A 1997
(Cytomegalovirus Infections...) :
Interferon-alpha/beta inhibition of interleukin 12 and
interferon-gamma production in vitro and endogenously during viral infection ... Both IFN-alpha and
IFN-beta inhibited fixed Staphylococcus aureus Cowan strain induction of IL-12 and
IFN-gamma production by mouse splenic leukocytes in culture
Arnason et al., J Neural Transm Suppl 1997
(Demyelinating Diseases...) :
IFN beta-1b also
inhibits release of lymphotoxin, tumor necrosis factor, and
interferon gamma , at least in vitro
Hunter et al., Immunol Lett 1997
:
IFN-alpha/beta alone
stimulated low levels of
IFN-gamma production by purified populations of IL-2 activated NK cells but in combination with IL-12 resulted in the production of significant levels of IFN-gamma ... Further studies revealed that TNF-alpha enhanced the ability of
IFN-alpha/beta to
stimulate production of
IFN-gamma by NK cells ... In contrast to the stimulatory
effect of
IFN-alpha/beta on NK cell production of
IFN-gamma , IFN-alpha/beta inhibited IL-2 induced proliferation of NK cells
Revel et al., Mult Scler 1995
(Breast Neoplasms...) :
In addition, study of MS patients treated with natural IFN-beta shows that
IFN-beta significantly
reduces serum levels of
IFN-gamma while increasing IL-4, strongly suggesting that IFN-beta also controls the relative activation of TH1- and TH2-type T lymphocytes
Satoh et al., Mult Scler 1996
:
The antagonistic
effect of
IFN-alpha/IFN-beta on the growth promoting activity of
IFN-gamma in cultured human astrocytes suggests that interferons serve as growth regulators of astrocytes at sites of reactive gliosis lesions of MS
Asipu et al., Biochim Biophys Acta 1998
:
In OL,
IFN-alpha/beta caused little induction of CAT activity, but
IFN-gamma resulted in a 2-3.5-fold decrease in CAT activity
Weber et al., Ann Neurol 1998
(Multiple Sclerosis) :
In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive
effect of
IFN-beta1b and the phosphodiesterase inhibitor pentoxifylline ( PTX ) on proliferation and the production of tumor necrosis factor-alpha (TNF-alpha), lymphotoxin ( LT ), and
interferon-gamma (IFN-gamma)
Van Weyenbergh et al., J Immunol 1998
(Multiple Sclerosis) :
In view of the antagonism of IFN-beta on IFN-gamma action, of interest in the chronic inflammatory disorder multiple sclerosis, we examined the possible
effect of
IFN-beta on
IFN-gamma induction of Fc gamma RI gene expression
Liu et al., J Immunol 1998
:
However,
IFN-gamma also
suppresses the expression of
IFN-beta- and IL-4 induced IL-1Ra so that IFN-gamma may enhance or suppress IL-1 activity depending on the other cytokines present
Mahalingam et al., J Virol 1999
:
MuMig ( murine monokine induced by gamma interferon ) and Crg-2 ( cytokine responsive gene 2 ) are two murine chemokines of the CXC family that are
induced by the interferons ( IFNs ) : MuMig specifically by
IFN-gamma and Crg-2 by IFN-alpha,
IFN-beta , and IFN-gamma