Gene interactions and pathways from curated databases and text-mining

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IFI27 — SRC

Text-mined interactions from Literome

Riley et al., Oncogene 2001 : Activating a temperature sensitive v-Src in quiescent cells sequentially induced cyclins D1, E and A and also down regulated p27
Choudhury et al., Cell Signal 2006 : Furthermore, inhibition of c-Src increased p27 ( Kip1 ) cyclin kinase inhibitor, and attenuated PDGF induced pRb phosphorylation and CDK2 activity
Chu et al., Cell 2007 (Breast Neoplasms...) : Importantly, we report that in tamoxifen-resistant breast cancer cell lines, Src inhibition can increase p27 levels and restore tamoxifen sensitivity