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IFI27 — SRC
Text-mined interactions from Literome
Riley et al., Oncogene 2001
:
Activating a temperature sensitive
v-Src in quiescent cells sequentially induced cyclins D1, E and A and also down
regulated p27
Choudhury et al., Cell Signal 2006
:
Furthermore, inhibition of
c-Src increased
p27 ( Kip1 ) cyclin kinase inhibitor, and attenuated PDGF induced pRb phosphorylation and CDK2 activity
Chu et al., Cell 2007
(Breast Neoplasms...) :
Importantly, we report that in tamoxifen-resistant breast cancer cell lines,
Src inhibition can
increase p27 levels and restore tamoxifen sensitivity