Gene interactions and pathways from curated databases and text-mining

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HNF1A — MAP2K3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: HNF1A → Complex of DYRK1B-MAP2K3 (increases, DYRK1B/MAP2K3 Activity) Lim et al., J Biol Chem 2002*
    Evidence: Mirk co-immunoprecipitated with the MAPK kinase MKK3, an upstream activator of p38. MKK3 enhanced Mirk kinase activity and the transcriptional activation of HNF-1alpha by Mirk