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FKBP1A — RPTOR

Pathways - manually collected, often from reviews:

• WikiPathways Target Of Rapamycin (TOR) Signaling: FKBP1A → Complex of RPTOR-MLST8-MTOR (inhibition)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RPTOR — FKBP1A (physical association, affinity chromatography technology) Sarbassov et al., Curr Biol 2004
• IRef Biogrid Interaction: RPTOR — FKBP1A (physical association, affinity chromatography technology) Jacinto et al., Nat Cell Biol 2004

Text-mined interactions from Literome

Oshiro et al., Genes Cells 2004 : Rapamycin, in the presence of FKBP12 , inhibited the association of raptor with mTOR directly in vitro, and concomitantly reduced the mTOR catalysed phosphorylation of raptor dependent, but not raptor independent substrates ; mTOR autophosphorylation was unaltered
Sarbassov et al., Curr Biol 2004 : Consistent with this finding, the rictor containing mTOR complex contains GbetaL but not raptor and it neither regulates the mTOR effector S6K1 nor is it bound by FKBP12-rapamycin
Hoeffer et al., Neuron 2008 (Synaptic Transmission) : Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior