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EGF — SOS2
Text-mined interactions from Literome
Akamatsu et al., J Biol Chem 1999
:
Phosphatase treatment of lysates restored the binding of Sos to vinexin, suggesting that signaling from serum,
EGF , or PDGF
regulates the
vinexin-Sos complex through the Sos phosphorylation
Oh-hora et al., J Exp Med 2003
:
The BCR requires RasGRP3 ; in contrast,
epidermal growth factor receptor is
dependent on Sos1 and
Sos2
Zhao et al., Nat Cell Biol 2007
:
This interaction is essential for
epidermal growth factor (EGF) induced
Sos membrane recruitment and Ras activation
Medema et al., Mol Cell Biol 1994
:
Calcium treatment, however, did not interfere with
EGF induced EGF receptor autophosphorylation or association of mammalian
SOS with the EGF receptor and Shc
Basu et al., Oncogene 1994
:
The binding of
Sos to tyrosine phosphorylated receptor, via Grb2 may also
contribute to Ras activation by
EGF but not NGF, while stable complex formation between Shc and receptors is not necessary for Ras activation by either growth factor
Holt et al., J Biol Chem 1996
:
Although
EGF stimulation of the mutant EGF receptor
activates ERK and phosphorylation of both Shc and
SOS , it fails to directly associate with either Shc or Grb2
Douville et al., Oncogene 1997
:
EGF induced
SOS phosphorylation in PC12 cells involves P90 RSK-2
Ishiki et al., Endocrinology 1997
:
Neither insulin nor
EGF treatment
induced Crk-II association with either
Sos or C3G
Kavanagh et al., Radiat Res 1998
:
In contrast,
EGF activated
SOS as shown by the enhanced association of SOS with EGFR in co-immunoprecipitation experiments